European Molecular Biology Laboratory, EMBL-European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridge, UK.
Applied Bioinformatics, Computer Science Department, University of Tübingen, Tübingen, Germany.
Proteomics. 2024 Feb;24(3-4):e2200403. doi: 10.1002/pmic.202200403. Epub 2023 Oct 3.
Although Top-down (TD) proteomics techniques, aimed at the analysis of intact proteins and proteoforms, are becoming increasingly popular, efforts are needed at different levels to generalise their adoption. In this context, there are numerous improvements that are possible in the area of open science practices, including a greater application of the FAIR (Findable, Accessible, Interoperable, and Reusable) data principles. These include, for example, increased data sharing practices and readily available open data standards. Additionally, the field would benefit from the development of open data analysis workflows that can enable data reuse of public datasets, something that is increasingly common in other proteomics fields.
虽然旨在分析完整蛋白质和蛋白质异构体的自上而下（TD）蛋白质组学技术越来越受欢迎，但仍需要在不同层面上努力推广其应用。在这方面，开放科学实践领域有许多可以改进的地方，包括更广泛地应用 FAIR（可发现、可访问、可互操作和可重复使用）数据原则。例如，增加数据共享实践和现成的开放数据标准。此外，该领域还将受益于开发开放数据分析工作流程，从而能够重复使用公共数据集的数据，这在其他蛋白质组学领域越来越普遍。
