Yeap Keng Han, Garner David, Sturridge Lydia
Cardiology, London North West University Healthcare National Health Service (NHS) Trust, London, GBR.
Infectious Disease, Frimley Health National Health Service (NHS) Foundation Trust, Camberley, GBR.
Cureus. 2023 Sep 2;15(9):e44559. doi: 10.7759/cureus.44559. eCollection 2023 Sep.
Infective endocarditis (IE) is life-threatening and can lead to complications if left untreated. A 56-year-old gentleman presented with acute delirium, fever and rigor. Panton-Valentine leukocidin (PVL)-positive () was isolated in the blood culture and the PR interval was prolonged on the electrocardiogram (ECG). However, the transthoracic echocardiogram (TTE) and transoesophageal echocardiogram (TOE) at presentation were unremarkable with no evidence of intracardiac vegetations. Despite expedient intravenous antibiotics, an acquired ventricular septal defect (VSD) developed, which required urgent cardiothoracic surgical repair. It is imperative to consider early surgical interventions and the use of anti-toxin antibiotics in PVL-positive IE.
感染性心内膜炎（IE）危及生命，若不治疗可导致并发症。一名56岁男性患者出现急性谵妄、发热和寒战。血培养分离出杀白细胞素（PVL）阳性的[具体细菌名称未给出]，心电图（ECG）显示PR间期延长。然而，就诊时经胸超声心动图（TTE）和经食管超声心动图（TOE）未见异常，无心脏内赘生物证据。尽管及时给予静脉抗生素治疗，但仍出现了获得性室间隔缺损（VSD），需要紧急进行心胸外科手术修复。对于PVL阳性的[具体细菌名称未给出]感染性心内膜炎，必须考虑早期手术干预和使用抗毒素抗生素。
