Skrypin V I, Brusovanik V I, Dzhaparidze L M, Erin A N, Selishcheva A A
Biull Eksp Biol Med. 1986 Nov;102(11):547-9.
Using fluorescent probes it has been shown that free fatty acids cause depolarization of synaptosomes isolated from the rat brain. At the same time free fatty acids stimulated 45Ca2+ transport into synaptosomes. It has been demonstrated that synaptosomes isolated from the brain of E-deficient rats were more sensitive to the action of free fatty acids. Depolarization of synaptosomes isolated from the brain of both control and E-deficient rats were reduced by the addition of exogenous alpha-tocopherol.
使用荧光探针已表明，游离脂肪酸会导致从大鼠大脑分离出的突触体去极化。与此同时，游离脂肪酸刺激了45Ca2+转运到突触体中。已经证明，从维生素E缺乏的大鼠大脑中分离出的突触体对游离脂肪酸的作用更敏感。添加外源性α-生育酚可降低从对照大鼠和维生素E缺乏大鼠大脑中分离出的突触体的去极化。
