Oite T
Acta Pathol Jpn. 1979 May;29(3):333-45.
The effects of surgical removal of the thymus or the administration of antiserum to thymus-derived lymphocytes on the development of Masugi nephritis were investigated in Wistar rats. While thymectomy at weaning (ATx) had no significant effect on the humoral antibody response to injected rabbit IgG, repeated injections of rabbit anti-rat thymocyte serum (ATS) suppressed it remarkably. Both treatments did not show morphological evidences that glomerular inflammation and injury were suppressed in the autologous phase of Masugi nephritis. Glomerular lesions in rats receiving the nephrotoxic serum (NTS) one month after ATx (ATx-1+NTS) appeared to be severer in hypercellularity, mitotic counts, the amount of deposited fibrin-related substances and crescent formation than those in other nephritic groups. Morphological study of ATS+NTS rats revealed that the glomerular changes were nearly equal to those of NTS-injected control rats, in spite of markedly suppressed humoral response to injected rabbit IgG and the absence of host IgG along the glomerular capillary walls.
在Wistar大鼠中研究了手术切除胸腺或给予抗胸腺来源淋巴细胞抗血清对Masugi肾炎发展的影响。虽然断奶时胸腺切除术（ATx）对注射兔IgG的体液抗体反应没有显著影响，但反复注射兔抗大鼠胸腺细胞血清（ATS）可显著抑制该反应。两种处理均未显示出在Masugi肾炎自体期肾小球炎症和损伤受到抑制的形态学证据。ATx后1个月接受肾毒性血清（NTS）的大鼠（ATx-1+NTS）的肾小球病变在细胞增多、有丝分裂计数、纤维蛋白相关物质沉积量和新月体形成方面似乎比其他肾炎组更严重。对ATS+NTS大鼠的形态学研究表明，尽管对注射兔IgG的体液反应明显受到抑制且沿肾小球毛细血管壁不存在宿主IgG，但肾小球变化与注射NTS的对照大鼠几乎相同。
