Siddiqui Ruqaiyyah, Khodja Abdelhamid, Ibrahim Taleb, Khamis Mustafa, Anwar Ayaz, Khan Naveed Ahmed
Microbiota Research Center, Istinye University, 34010, Istanbul, Turkey.
Department of Biology, Chemistry and Environmental Sciences, College of Arts and Sciences, American University of Sharjah, Sharjah, United Arab Emirates.
World J Microbiol Biotechnol. 2023 Oct 4;39(12):330. doi: 10.1007/s11274-023-03760-8.
With the rise of antibiotic resistance globally, coupled with evolving and emerging infectious diseases, there is an urgent need for the development of novel antimicrobials. Deep eutectic solvents (DES) are a new generation of eutectic mixtures that depict promising attributes with several biological implications. DES exhibit unique properties such as low toxicity, biodegradability, and high thermal stability. Herein, the antimicrobial properties of DES and their mechanisms of action against a range of microorganisms, including bacteria, amoebae, fungi, viruses, and anti-cancer properties are reviewed. Overall, DES represent a promising class of novel antimicrobial agents as well as possessing other important biological attributes, however, future studies on DES are needed to investigate their underlying antimicrobial mechanism, as well as their in vivo effects, for use in the clinic and public at large.
随着全球抗生素耐药性的上升，再加上不断演变和新出现的传染病，迫切需要开发新型抗菌药物。深共晶溶剂（DES）是新一代的共晶混合物，具有一些具有生物学意义的有前景的特性。DES具有低毒性、生物可降解性和高热稳定性等独特性质。本文综述了DES的抗菌特性及其对一系列微生物（包括细菌、变形虫、真菌、病毒）的作用机制以及抗癌特性。总体而言，DES是一类有前景的新型抗菌剂，还具有其他重要的生物学特性，然而，需要对DES进行进一步研究，以探究其潜在的抗菌机制及其体内效应，以便在临床和广大公众中使用。
