关节组织中持续性 E1 糖蛋白与炎症、纤维化及基孔肯雅热慢性关节病的关系。
Inflammation, fibrosis and E1 glycoprotein persistence in joint tissue of patients with post-Chikungunya chronic articular disease.
机构信息
Universidade de Cuiabá, Faculdade de Medicina, Departamento de Clínica Médica, Cuiabá, MT, Brasil.
Universidade Federal de Mato Grosso, Faculdade de Medicina, Programa de Pós-Graduação em Ciências da Saúde, Cuiabá, MT, Brasil.
出版信息
Rev Soc Bras Med Trop. 2023 Sep 22;56:e02782023. doi: 10.1590/0037-8682-0278-2023. eCollection 2023.
INTRODUCTION
Chikungunya chronic joint disease causes debilitating arthralgia, significantly impacting the quality of life of affected individuals.
METHODS
In this study, patients underwent clinical follow-ups, joint biopsies, and pre-biopsy and 24 months post-biopsy serum dosage of cytokines.
RESULTS
All participants were female and had pain in 12 joints on average, with 41.17% exhibiting moderate disease activity. Histopathological analysis revealed collagen deposition. Indirect immunofluorescence detected the CHIKV glycoprotein E1 antigen, and an increase in cytokines.
CONCLUSIONS
Persistent inflammation and ineffective antiviral immune responses leading to antigen persistence may contribute to chronic CHIKV arthritis.
简介
基孔肯雅慢性关节病可引起使人虚弱的关节痛，严重影响受影响者的生活质量。
方法
在这项研究中，患者接受了临床随访、关节活检以及活检前和活检后 24 个月的细胞因子血清检测。
结果
所有参与者均为女性，平均有 12 个关节疼痛，41.17%的患者表现出中度疾病活动度。组织病理学分析显示存在胶原蛋白沉积。间接免疫荧光检测到基孔肯雅病毒糖蛋白 E1 抗原和细胞因子增加。
结论
持续的炎症和无效的抗病毒免疫反应导致抗原持续存在可能导致慢性基孔肯雅病毒关节炎。
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