Rheumatology Department, Lapeyronie Hospital, Montpellier University, CHU Lapeyronie-191 Av. du Doyen Gaston Giraud, 34295, cedex 5, Montpellier, France.
Curr Rheumatol Rep. 2017 Oct 5;19(11):69. doi: 10.1007/s11926-017-0694-0.
Chikungunya virus (CHIKV) infection has become increasingly prevalent in the last decade not only across the southern hemisphere but also, because of a recently documented viral mutation, in southern Europe and the USA. With the global spread of CHIKV infection, practitioners should know its epidemiology, pathophysiology and clinical features.
The acute phase of CHIKV disease is characterised by a fever-arthralgia-rash syndrome. Chronic rheumatic manifestations can persist for months to years with very variable clinical presentations. Some cases mimic inflammatory rheumatism such as rheumatoid arthritis. Several risk factors for persistent joint pain, notably older age, have been identified in cohort studies. Despite a low mortality rate with CHIKV infection, the rate of disability with chronic joint symptoms is high, and effective treatments are lacking. Current research is focusing on the development of vaccines and antiviral drugs, and data on treatment of CHIKV-induced chronic arthritis are needed.
基孔肯雅病毒（CHIKV）感染在过去十年中不仅在南半球变得越来越普遍，而且由于最近记录的病毒突变，在南欧和美国也变得越来越普遍。随着 CHIKV 感染的全球传播，医生应该了解其流行病学、病理生理学和临床特征。
CHIKV 疾病的急性期以发热-关节痛-皮疹综合征为特征。慢性风湿表现可持续数月至数年，临床表现非常多变。一些病例类似于类风湿关节炎等炎症性风湿病。队列研究确定了一些持续性关节痛的风险因素，特别是年龄较大。尽管 CHIKV 感染的死亡率较低，但慢性关节症状的残疾率很高，而且缺乏有效的治疗方法。目前的研究集中在疫苗和抗病毒药物的开发上，需要有关 CHIKV 引起的慢性关节炎治疗的数据。
