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合作研究酒精中毒的遗传学:合作、团队科学和纵向数据的力量。

Collaborative study on the genetics of alcoholism: The strength of collaboration, team science, and longitudinal data.

机构信息

Institute for Behavioral Genetics and the Department of Integrative Physiology, University of Colorado, Boulder, Colorado, USA.

出版信息

Genes Brain Behav. 2023 Oct;22(5):e12866. doi: 10.1111/gbb.12866. Epub 2023 Sep 19.

Abstract

This issue contains a series of articles describing the various resources, studies, results, and future directions for the collaborative study on the genetics of alcoholism (COGA). The collaborative and integrative approach initiated by this group ~30 years ago serves as an excellent example of the strength of team science. Individually, various aspects of COGA would be limited in their impact toward improved understanding of alcohol use disorder. Collectively, their wholistic approach which spans deep longitudinal phenotypic assessments in families to include the application of large-scale omics technologies and cell-culture based molecular studies has demonstrated the power of working together.

摘要

本期特刊载有一系列文章,介绍酗酒遗传学协作研究(COGA)的各种资源、研究、成果及未来方向。该研究组于约 30 年前开创了这种协作和综合的方法,堪称团队科学优势的一个绝佳范例。COGA 的各个方面如果各自为战,其影响可能会局限于增进对酒精使用障碍的理解。但它们采取的整体方法将家庭中的深度纵向表型评估与大规模组学技术和基于细胞培养的分子研究结合起来,已经显示出了合作的力量。

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The collaborative study on the genetics of alcoholism: Genetics.协作研究酒精中毒的遗传学:遗传学。
Genes Brain Behav. 2023 Oct;22(5):e12856. doi: 10.1111/gbb.12856. Epub 2023 Jun 30.
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The collaborative study on the genetics of alcoholism: Brain function.酒精中毒遗传学的协作研究:脑功能。
Genes Brain Behav. 2023 Oct;22(5):e12862. doi: 10.1111/gbb.12862. Epub 2023 Aug 17.

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