Mchedlishvili G, Varazashvili M
Brain Res. 1986 Oct 29;386(1-2):64-8. doi: 10.1016/0006-8993(86)90141-1.
In experiments with anesthetized rabbits we found that blood in various branches of the aortic arch has unequal content of red cells. The blood flowing via the carotid arteries to the head contained significantly greater red cell concentration and hematocrit than that flowing via the abdominal aorta to the hind legs. Furthermore, the blood flowing via the right brachial artery to the corresponding foreleg showed a significantly higher red cell concentration and hematocrit than the blood carried via the left brachial artery to the respective foreleg. This phenomenon of unequal distribution of red cells from the aorta to various arterial branches results in that the brain is supplied with blood containing a higher number of oxygen carriers, i.e. red cells, than caudal parts of the body. On the other hand, the higher red cell content of the blood in the right foreleg, as compared to the left one, might in a certain way contribute to asymmetry of the forelegs, and thence of the brain, in the evolutionary process of vertebrates. A possible mechanism of the described hemodynamic phenomenon is discussed.
在对麻醉兔进行的实验中，我们发现主动脉弓各分支中的血液红细胞含量不均等。流经颈动脉至头部的血液，其红细胞浓度和血细胞比容显著高于流经腹主动脉至后肢的血液。此外，流经右肱动脉至相应前肢的血液，其红细胞浓度和血细胞比容明显高于经左肱动脉至相应前肢的血液。红细胞从主动脉到各动脉分支分布不均的这种现象，导致大脑所接受的血液中含氧量载体（即红细胞）的数量高于身体尾部。另一方面，右前肢血液中红细胞含量高于左前肢，这可能在一定程度上促成了脊椎动物进化过程中前肢以及大脑的不对称性。文中讨论了所描述的这种血液动力学现象的可能机制。
