Chen Huihui, Zhang Guolei, He Lei, Zhou Wei, Zhang Shenglei, Niu Zhe Zhe, Jin Jingjing, Juan Cheng Mei, Guo Liping, Liang Xiang Nan, Zhu Rong Fang, Zhang Huiran, Bai Yaling, Xu Jin Sheng
The Fourth Hospital of Hebei Medical University, Department of Nephrology, Hebei Key Laboratory of Vascular Calcification in Kidney Disease, Hebei Clinical Research Center for Chronic Kidney Disease, 12 Jian kang Road, Shijiazhuang, 050011, P.R. China.
Department of Orthopedics, The Third Hospital of Hebei Medical University, Shijiazhuang, P.R. China.
BMC Cardiovasc Disord. 2023 Oct 4;23(1):490. doi: 10.1186/s12872-023-03533-z.
This study aimed to analyze the possible causes of changes in cardiac function and investigate the feasibility of clinical assessment of gastrointestinal cancer in patients with or without acute kidney injury (AKI) assessed using a non-invasive impedance cardiography (ICG, Bioz. Cardio Dynamics, USA) to identify independent risk factors.
Patients admitted to the Fourth Hospital of Hebei Medical University, China, between May 1, 2019, and February 15, 2022, were included in this study. A total of 51 patients with gastrointestinal cancer (31 men and 20 women, mean age 61.1 ± 10.9 years) with or without AKI were evaluated for ICG. A total of 19 patients underwent ultrasound cardiography (UCG) and ICG evaluations.
There was a significant positive correlation between cardiac output (CO), cardiac index (CI), stroke volume (SV), left cardiac work index (LCWI), and ejection fraction (EF) measured using UCG and ICG. The relationship was observed between CO and CO (r = 0.707, P = 0.001), CI and CI (r = 0.718, P = 0.001), SV and SV (r = 0.837, P < 0.001), and LCWI and EF (r = 0.540, P = 0.017). Cardiac function parameters measured using ICG were statistically different between patients with gastrointestinal cancer with or without AKI (P ≤ 0.05). Multivariate analysis revealed that AKI independently affects cardiac function in patients with gastrointestinal cancer.
UCG and ICG methods are significantly associated with cardiac function in patients with or without AKI, and patients with gastrointestinal cancer with AKI are worse than those without AKI. AKI is an independent risk factor for cardiac function in patients with gastrointestinal cancer.
本研究旨在分析心功能变化的可能原因，并探讨使用无创阻抗心动图（ICG，美国Bioz. Cardio Dynamics公司）评估有无急性肾损伤（AKI）的胃肠道癌患者临床评估的可行性，以确定独立危险因素。
纳入2019年5月1日至2022年2月15日在中国河北医科大学第四医院住院的患者。共有51例有无AKI的胃肠道癌患者（31例男性和20例女性，平均年龄61.1±10.9岁）接受了ICG评估。共有19例患者接受了超声心动图（UCG）和ICG评估。
使用UCG和ICG测量的心输出量（CO）、心脏指数（CI）、每搏输出量（SV）、左心做功指数（LCWI）和射血分数（EF）之间存在显著正相关。观察到CO与CO之间的关系（r = 0.707，P = 0.001）、CI与CI之间的关系（r = 0.718，P = 0.001）、SV与SV之间的关系（r = 0.837，P < 0.001）以及LCWI与EF之间的关系（r = 0.540，P = 0.017）。有无AKI的胃肠道癌患者使用ICG测量的心功能参数存在统计学差异（P≤0.05）。多因素分析显示，AKI独立影响胃肠道癌患者的心功能。
UCG和ICG方法与有无AKI患者的心功能显著相关，有AKI的胃肠道癌患者比无AKI的患者情况更差。AKI是胃肠道癌患者心功能的独立危险因素。
