性类固醇对大鼠副嗅球中两个颗粒细胞亚群发育的影响。
Effects of sex steroids on the development of two granule cell subpopulations in the rat accessory olfactory bulb.
作者信息
Segovia S, Valencia A, Calés J M, Guillamón A
出版信息
Brain Res. 1986 Dec;395(2):283-6. doi: 10.1016/s0006-8993(86)80209-8.
The effects of postnatal male castration on day 1 (D1) after birth and female androgenization on accessory olfactory bulb (AOB) light and dark granule cell populations were studied. Control males showed a greater number of both light and dark AOB granule cells than females. Postnatal treatment reversed these differences in the light granule cells. Female androgenization on D1 does not affect the number of AOB dark granule cells. However, male orchidectomy also on D1 significantly decreases the number of dark granule cells. Androgens injected into female rats are able to increase the number of AOB dark granule cells if they are administered on D14. This suggests a different critical period for the early effects of androgens on the dark granule cells with respect to light granule cells.
研究了出生后第1天（D1）对雄性进行阉割以及对雌性进行雄激素化处理对副嗅球（AOB）中明、暗两种颗粒细胞群的影响。对照雄性的明、暗两种AOB颗粒细胞数量均多于雌性。出生后的处理逆转了明颗粒细胞的这些差异。出生第1天对雌性进行雄激素化处理不影响AOB暗颗粒细胞的数量。然而，同样在出生第1天对雄性进行睾丸切除则显著减少了暗颗粒细胞的数量。如果在出生第14天给雌性大鼠注射雄激素，则能够增加AOB暗颗粒细胞的数量。这表明雄激素对暗颗粒细胞早期影响的关键时期与明颗粒细胞不同。
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