Section of Periodontology, Department of Conservative Dentistry, Clinic for Oral, Dental and Maxillofacial Diseases, Heidelberg University Hospital, Heidelberg, Germany.
Department of Pneumology and Critical Care Medicine, Thoraxklinik, Translational Lung Research Center Heidelberg (TLRCH) of the German Center for Lung Research (DZL), University of Heidelberg, Heidelberg, Germany.
Oral Dis. 2024 Jul;30(5):3400-3412. doi: 10.1111/odi.14755. Epub 2023 Oct 4.
This study aimed to investigate the association of explicitly severe chronic obstructive pulmonary disease (COPD) with oral conditions considering in-depth shared risk factors.
A case-control study was conducted with 104 participants, 52 with severe COPD and 52 matched controls without COPD. Dental and periodontal status were clinically assessed and oral health-related quality of life (OHRQoL) by OHIP-G14-questionnaire.
Between COPD- and control-group, there were no statistically significant differences regarding age (66.02 ± 7.30), sex (female: 52 [50%]), smoking history (44.69 ± 23.23 pack years) and number of systemic diseases (2.60 ± 1.38). COPD patients demonstrated significantly fewer remaining teeth (12.58 ± 9.67 vs. 18.85 ± 6.24, p < 0.001) besides higher DMFT (decayed, missing and filled teeth) index (21.12 ± 5.83 vs. 19.10 ± 3.91, p = 0.036). They had significantly greater probing pocket depths (PPD: 3.24 mm ± 0.71 mm vs. 2.7 mm ± 0.37 mm, p < 0.001) and bleeding on probing (BOP: 34.52% ± 22.03% vs. 22.85% ± 17.94%, p = 0.003) compared to controls, but showed no significant difference in clinical attachment level or staging of periodontitis. The OHIP-G14 sum score was significantly higher in COPD patients (7.40 ± 7.28 vs. 3.63 ± 4.85, p = 0.002). Common risk factors such as educational status, physical activity, dentist visit frequency, oral hygiene regimens and dietary habits were less favourable in patients with COPD.
COPD was significantly associated with higher tooth loss, PPD, BOP and DMFT besides lower OHRQoL.
本研究旨在探讨在考虑到深入的共同危险因素的情况下，明确的严重慢性阻塞性肺疾病（COPD）与口腔状况的关联。
采用病例对照研究，共纳入 104 名参与者，其中 52 名患有严重 COPD，52 名匹配的无 COPD 对照。临床评估了牙齿和牙周状况，并通过 OHIP-G14 问卷评估了口腔健康相关生活质量（OHRQoL）。
COPD 组和对照组在年龄（66.02±7.30）、性别（女性：52 [50%]）、吸烟史（44.69±23.23 包年）和全身性疾病数量（2.60±1.38）方面无统计学差异。COPD 患者的剩余牙齿明显较少（12.58±9.67 颗 vs. 18.85±6.24 颗，p<0.001），此外 DMFT（龋齿、缺失和填充牙齿）指数更高（21.12±5.83 vs. 19.10±3.91，p=0.036）。与对照组相比，COPD 患者的探诊袋深度（PPD：3.24mm±0.71mm 与 2.7mm±0.37mm，p<0.001）和探诊出血（BOP：34.52%±22.03% 与 22.85%±17.94%，p=0.003）显著增加，但在临床附着水平或牙周炎分期方面无显著差异。COPD 患者的 OHIP-G14 总分明显更高（7.40±7.28 与 3.63±4.85，p=0.002）。COPD 患者的教育程度、体力活动、看牙医频率、口腔卫生方案和饮食习惯等常见危险因素较差。
COPD 与牙齿缺失、PPD、BOP 和 DMFT 增加以及 OHRQoL 降低显著相关。
