Ha Ling-Xia, Du Yu-Dong, Qu Xiao-Xiao, Wang Jin-Juan
Reproductive Medicine Center, General Hospital of Ningxia Medical University, Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan, Ningxia, 750004, People's Republic of China.
Ningxia Medical University, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, People's Republic of China.
Diabetes Metab Syndr Obes. 2023 Sep 28;16:3019-3027. doi: 10.2147/DMSO.S430120. eCollection 2023.
The purpose of this study was to explore the relationship between hemoglobin levels and metabolic disorders in patients with PCOS.
A total of 573 patients were selected, based on the hemoglobin level; 342 patients with PCOS were divided into two groups as follows: Group A (normal Hb group, n = 269) and Group B (high Hb group, n = 73); 231 non-PCOS patients were divided into two groups as follows: Group C (normal Hb group, n = 199), and Group D (high Hb group, n = 32). The general information, glucose and lipid metabolism indicators, and uric acid levels of all patients were compiled for data analysis.
(1) Hb, HGB concentration in mean red blood cells and RDW in PCOS patients were higher than those in non-PCOS patients, and MCV was lower than that in non-PCOS patients ( < 0.05); (2) Compared with Group A, patients in Group B had higher BMI, Hb, 2-hPG, FINS, 2-hINS, HOMA-IR, LDL-C, and uric acid levels while the QUICKI was lower; in Group C, the age, FSH, HDL-C, and LDL-C were higher, and AMH, BMI, T, TG, and uric acid level were lower (<0.05); compared with Group D, AMH, BMI, FINS, HOMA-IR, TG, uric acid level increased, while age, FSH, and QUICKI decreased in Group B; and Hb and T decreased in Group C (<0.05); (3) Pearson's correlation analysis indicated that Hb in PCOS patients was positively correlated with BMI, FPG, 2-hPG, FINS, 2-hINS, and HOMA-IR, and negatively correlated with the QUICKI (<0.05); (4) Multi-factor logistic regression analysis suggested that the high Hb level in PCOS patients was an independent risk factor of IR (<0.05).
Hb level in patients with PCOS was associated with BMI and glucose metabolism indicators; a high Hb level may be an independent risk factor for IR.
本研究旨在探讨多囊卵巢综合征（PCOS）患者血红蛋白水平与代谢紊乱之间的关系。
根据血红蛋白水平选取573例患者；342例PCOS患者分为两组：A组（正常血红蛋白组，n = 269）和B组（高血红蛋白组，n = 73）；231例非PCOS患者分为两组：C组（正常血红蛋白组，n = 199）和D组（高血红蛋白组，n = 32）。汇总所有患者的一般信息、糖脂代谢指标及尿酸水平进行数据分析。
（1）PCOS患者的血红蛋白（Hb）、平均红细胞血红蛋白浓度（HGB）及红细胞分布宽度（RDW）高于非PCOS患者，平均红细胞体积（MCV）低于非PCOS患者（P < 0.05）；（2）与A组相比，B组患者的体重指数（BMI）、Hb、餐后2小时血糖（2-hPG）、空腹胰岛素（FINS）、餐后2小时胰岛素（2-hINS）、稳态模型评估胰岛素抵抗指数（HOMA-IR）、低密度脂蛋白胆固醇（LDL-C）及尿酸水平较高，而定量胰岛素敏感性检查指数（QUICKI）较低；C组患者的年龄、促卵泡生成素（FSH）、高密度脂蛋白胆固醇（HDL-C）及LDL-C较高，抗缪勒管激素（AMH）、BMI、睾酮（T）、甘油三酯（TG）及尿酸水平较低（P < 0.05）；与D组相比，B组患者的AMH、BMI、FINS、HOMA-IR、TG及尿酸水平升高，而年龄、FSH及QUICKI降低；C组患者的Hb及T降低（P < 0.05）；（3）Pearson相关性分析表明，PCOS患者的Hb与BMI、空腹血糖（FPG）、2-hPG、FINS、2-hINS及HOMA-IR呈正相关，与QUICKI呈负相关（P < 0.05）；（4）多因素logistic回归分析提示，PCOS患者的高Hb水平是胰岛素抵抗（IR）的独立危险因素（P < 0.05）。
PCOS患者的Hb水平与BMI及糖代谢指标相关；高Hb水平可能是IR的独立危险因素。
