Virtanen Nikke, Pesonen Emilia, Saarela Ulla, Hurskainen Elisa, Arffman Riikka K, Koivunen Peppi, Piltonen Terhi
Department of Obstetrics and Gynecology, Medical Research Centre, Research Unit of Clinical Medicine, University of Oulu, Oulu University Hospital, Oulu, Finland.
Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.
Acta Obstet Gynecol Scand. 2025 Feb;104(2):357-367. doi: 10.1111/aogs.15047. Epub 2024 Dec 30.
Within normal variation, higher hemoglobin (Hb) levels are associated with poorer metabolic profile in population cohorts, underlying the link between oxygen delivery and cell metabolism. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women and is commonly accompanied by metabolic derangements. In this study we sought to investigate Hb levels, and their metabolic associations, in women with PCOS.
We used data from Northern Finland Birth Cohort 1966 to evaluate Hb levels in women with or without PCOS at the ages of 31 and 46 years. Linear regression models were used to investigate associations between Hb levels and essential metabolic parameters in both groups.
Women with PCOS had higher Hb levels than controls at the age of 31 years but not at the age of 46 years. Hb levels were associated positively with most of the metabolic parameters tested (body mass index, waist circumference, fasting insulin, homeostatic model assessment-insulin resistance (HOMA-IR), blood pressure, inflammatory markers, and blood lipids), with stronger associations in women with PCOS than in non-PCOS controls. There were fewer associations at the age of 46 than at 31 years, and body mass index seemed to explain many, though not all, differences between the PCOS and non-PCOS groups.
Women with PCOS have higher Hb levels at the age of 31 years. In both women with and without PCOS, Hb levels associate with poorer metabolic profile.
在正常变异范围内，人群队列中较高的血红蛋白（Hb）水平与较差的代谢状况相关，这揭示了氧输送与细胞代谢之间的联系。多囊卵巢综合征（PCOS）是女性中最常见的内分泌疾病，常伴有代谢紊乱。在本研究中，我们旨在调查PCOS女性的Hb水平及其代谢关联。
我们使用了1966年芬兰北部出生队列的数据，以评估31岁和46岁时有或无PCOS的女性的Hb水平。使用线性回归模型研究两组中Hb水平与基本代谢参数之间的关联。
31岁时，PCOS女性的Hb水平高于对照组，但46岁时并非如此。Hb水平与大多数测试的代谢参数（体重指数、腰围、空腹胰岛素、稳态模型评估-胰岛素抵抗（HOMA-IR）、血压、炎症标志物和血脂）呈正相关，PCOS女性中的相关性比非PCOS对照组更强。46岁时的关联比31岁时少，体重指数似乎解释了PCOS组和非PCOS组之间的许多（尽管不是全部）差异。
31岁时，PCOS女性的Hb水平较高。在有和没有PCOS的女性中，Hb水平均与较差的代谢状况相关。
