Department of Nano-Biomedical Engineering, Advanced Science Institute, Yonsei University, Seoul, Republic of Korea.
Center for Nanomedicine, Institute for Basic Science, Seoul, Republic of Korea.
Front Immunol. 2023 Sep 13;14:1264721. doi: 10.3389/fimmu.2023.1264721. eCollection 2023.
T cell activation is initiated by the recognition of specific antigenic peptides and subsequently accomplished by complex signaling cascades. These aspects have been extensively studied for decades as pivotal factors in the establishment of adaptive immunity. However, how receptors or signaling molecules are organized in the resting state prior to encountering antigens has received less attention. Recent advancements in super-resolution microscopy techniques have revealed topographically controlled pre-formed organization of key molecules involved in antigen recognition and signal transduction on microvillar projections of T cells before activation and substantial effort has been dedicated to characterizing the topological structure of resting T cells over the past decade. This review will summarize our current understanding of how key surface receptors are pre-organized on the T-cell plasma membrane and discuss the potential role of these receptors, which are preassembled prior to ligand binding in the early activation events of T cells.
T 细胞的激活是由对特定抗原肽的识别引发的，随后通过复杂的信号级联反应完成。几十年来，这些方面一直是适应性免疫建立的关键因素，被广泛研究。然而，在遇到抗原之前，受体或信号分子在静止状态下是如何组织的，这方面的研究还较少。近年来，超分辨率显微镜技术的进步揭示了在 T 细胞微绒毛突起上，参与抗原识别和信号转导的关键分子在激活前就已经存在拓扑控制的预形成组织。过去十年中，人们致力于对静止 T 细胞的拓扑结构进行特征描述，这方面的工作取得了相当大的进展。本文将总结我们目前对关键表面受体在 T 细胞膜上如何预组织的理解，并讨论这些受体在 T 细胞早期激活事件中的潜在作用，即在配体结合之前，这些受体就已经预先组装。
