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跨膜蛋白酪氨酸磷酸酶CD45对B淋巴细胞和T淋巴细胞激活的调节

The regulation of B- and T-lymphocyte activation by the transmembrane protein tyrosine phosphatase CD45.

作者信息

Thomas M L

机构信息

Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63110.

出版信息

Curr Opin Cell Biol. 1994 Apr;6(2):247-52. doi: 10.1016/0955-0674(94)90143-0.

DOI:10.1016/0955-0674(94)90143-0
PMID:8024816
Abstract

The expression of transmembrane protein tyrosine phosphatase CD45 is required for antigen-induced activation of T and B lymphocytes. During the past year, advances have been made in our understanding of CD45 regulation and its role in regulating Src-family members. The importance of CD45 in thymocyte maturation has been demonstrated through the generation of CD45-knockout mice.

摘要

跨膜蛋白酪氨酸磷酸酶CD45的表达是抗原诱导T和B淋巴细胞激活所必需的。在过去的一年里，我们对CD45调节及其在调节Src家族成员中的作用的理解取得了进展。通过生成CD45基因敲除小鼠，已证明CD45在胸腺细胞成熟中的重要性。

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SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription.
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