Coulon J, Hakkou A, Mpona-Minga M, Bonaly R
Can J Microbiol. 1986 Sep;32(9):738-42.
The degree of sensitivity of the yeasts Kluyveromyces bulgaricus and K. lactis to amphotericin B is linked to a difference in the sterol composition of their membranes. No direct proportionality was found between sensitivity and the quantity of sterols present. At sublethal doses, amphotericin B perturbed sterol synthesis, resulting in ergosterol precursor accumulation. An ergosterol pathway is proposed for Kluyveromyces.
保加利亚乳杆菌和乳酸克鲁维酵母对两性霉素B的敏感程度与它们细胞膜中甾醇组成的差异有关。未发现敏感性与甾醇含量之间存在直接比例关系。在亚致死剂量下，两性霉素B干扰甾醇合成，导致麦角固醇前体积累。提出了乳酸克鲁维酵母的麦角固醇合成途径。
