Christiansen Alexandra Golabek, Kinnerup Martin Byskov, Carstensen Ole, Sommerlund Mette, Clausen Per Axel, Bønløkke Jakob Hjort, Schlünssen Vivi, Isaksson Marléne, Schmidt Sigrun Alba Johannesdottir, Kolstad Henrik Albert
Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark.
Department of Occupational Medicine, Danish Ramazzini Centre, The Regional Hospital Goedstrup, University Research Clinic, Herning, Denmark.
Contact Dermatitis. 2024 Jan;90(1):32-40. doi: 10.1111/cod.14431. Epub 2023 Oct 5.
Allergic contact allergy and dermatitis are frequently reported among epoxy-exposed workers.
To determine the risk of dermatitis associated with epoxy exposure.
We followed 825 epoxy-exposed and 1091 non-exposed blue-collar workers, and 493 white-collar workers of a Danish wind turbine blade factory during 2017-2022 with linked data from national health registers on diagnoses, patch testing, or fillings of prescriptions for topical corticosteroids. Incidence rate ratios of dermatitis or a first-time topical corticosteroid prescription were estimated with Poisson regression using non-exposed blue-collar workers as reference. We similarly estimated incidence rate ratios for the duration of epoxy exposure and current epoxy exposure.
Epoxy-exposed blue-collar workers showed a dermatitis incidence rate of 2.1 per 100 000 person days, a two-fold increased risk of dermatitis and a 20% increased risk of filling a prescription for topical corticosteroids. Incidence rate ratios were higher during early exposure and declined with further exposure for both outcomes. White-collar workers had generally lower risks.
We observed an increased risk of dermatitis following epoxy exposure confirming previous case reports and cross-sectional studies emphasizing the need for intensified focus on preventive efforts for this group of workers.
环氧暴露工人中经常报告有过敏性接触性过敏和皮炎。
确定与环氧暴露相关的皮炎风险。
在2017年至2022年期间，我们跟踪了丹麦一家风力涡轮机叶片工厂的825名环氧暴露蓝领工人、1091名未暴露蓝领工人以及493名白领工人，并将国家健康登记册中有关诊断、斑贴试验或外用皮质类固醇处方配药的相关数据进行了关联。以未暴露蓝领工人作为对照，采用泊松回归估计皮炎或首次外用皮质类固醇处方的发病率比。我们同样估计了环氧暴露持续时间和当前环氧暴露的发病率比。
环氧暴露蓝领工人的皮炎发病率为每100 000人日2.1例，患皮炎的风险增加两倍，外用皮质类固醇处方配药风险增加20%。两种结果在早期暴露时发病率比更高，随着进一步暴露而下降。白领工人的风险总体较低。
我们观察到环氧暴露后皮炎风险增加，证实了先前的病例报告和横断面研究，强调需要加强对这群工人的预防工作的关注。
