Department of Clinical Laboratory, Baoding First Central Hospital, Baoding, Hebei province, China.
Physiol Res. 2023 Aug 31;72(4):445-454. doi: 10.33549/physiolres.935092.
This analysis aims to see whether 6-shogaol could protect rats against D-galactosamine (D-GalN)-induced Hepatotoxicity. The Wistar rats were divided into four groups (n=6). Group 1 received a standard diet, Group 2 received an oral administration of 6-shogaol (20 mg/kg b.wt), Group 3 received an intraperitoneal injection of D-GalN (400 mg/kg b.wt) on 21st day, and Group 4 received an oral administration of 6-shogaol (20mg/kg b.wt) for 21 days and D-GalN (400 mg/kg b.wt) injection only on 21st day. The hepatic marker enzymes activity, lipid peroxidative markers level increased significantly and antioxidant activity/level significantly reduced in D-GalN-induced rats. 6-shogaol Pretreatment effectively improves the above changes in D-GalN-induced rats. Further, inflammatory marker expression and MAPK signaling molecules were downregulated by 6-shogaol. These findings showed that 6-shogaol exerts hepatoprotective effects via the enhanced antioxidant system and attenuated the inflammation and MAPK signaling pathway in D-GalN-induced rats.
本分析旨在研究 6-姜烯酚是否可以保护大鼠免受半乳糖胺（D-GalN）诱导的肝毒性。将 Wistar 大鼠分为四组（n=6）。第 1 组给予标准饮食，第 2 组给予 6-姜烯酚（20mg/kg b.wt）口服，第 3 组在第 21 天给予腹腔注射 D-GalN（400mg/kg b.wt），第 4 组给予 6-姜烯酚（20mg/kg b.wt）口服 21 天，仅在第 21 天给予 D-GalN（400mg/kg b.wt）注射。D-GalN 诱导的大鼠肝标志物酶活性、脂质过氧化标志物水平显著升高，抗氧化活性/水平显著降低。6-姜烯酚预处理可有效改善 D-GalN 诱导大鼠的上述变化。此外，6-姜烯酚下调了炎症标志物表达和 MAPK 信号分子。这些发现表明，6-姜烯酚通过增强抗氧化系统，减轻 D-GalN 诱导的大鼠炎症和 MAPK 信号通路，发挥其肝保护作用。
