Experimental Medicine Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Physiol Res. 2023 Aug 31;72(4):539-543. doi: 10.33549/physiolres.935108.
SARS-CoV-2 infection, which causes the respiratory disease COVID-19, has spread rapidly from Wuhan, China, since 2019, causing nearly 7 million deaths worldwide in three years. In addition to clinical risk factors such as diabetes, hypertension, and obesity, genetic variability is an important predictor of disease severity and susceptibility. We analyzed common polymorphisms within the LZTFL1 (rs11385942) and ABCA3 (rs13332514) genes in 519 SARS-CoV-2-positive subjects (164 asymptomatic, 246 symptomatic, and 109 hospitalized COVID-19 survivors) and a population-based control group (N?=?2,592; COVID-19 status unknown). Rare ABCA3 AA homozygotes (but not A allele carriers) may be at a significantly increased risk of SARS-CoV-2 infection [P?=?0.003; OR (95 % CI); 3.66 (1.47-9.15)]. We also observed a borderline significant difference in the genotype distribution of the LZTFL1 rs11385942 polymorphism (P?=?0.04) between the population sample and SARS-CoV-2-positive subjects. In agreement with previous studies, a nonsignificantly higher frequency of minor allele carriers was detected among hospitalized COVID-19 subjects. We conclude that a common polymorphism in the ABCA3 gene may be a significant predictor of susceptibility to SARS-CoV-2 infection.
自 2019 年以来，导致呼吸道疾病 COVID-19 的 SARS-CoV-2 感染已迅速从中国武汉蔓延开来，在三年内导致全球近 700 万人死亡。除了糖尿病、高血压和肥胖等临床危险因素外，遗传变异性也是疾病严重程度和易感性的重要预测因素。我们分析了 519 例 SARS-CoV-2 阳性受试者（164 例无症状、246 例有症状和 109 例住院 COVID-19 幸存者）和基于人群的对照组（N=2592；COVID-19 状态未知）中 LZTFL1（rs11385942）和 ABCA3（rs13332514）基因内常见的多态性。罕见的 ABCA3 AA 纯合子（而非 A 等位基因携带者）可能面临 SARS-CoV-2 感染的显著增加风险[P=0.003；OR（95%CI）；3.66（1.47-9.15）]。我们还观察到 LZTFL1 rs11385942 多态性在人群样本和 SARS-CoV-2 阳性受试者之间的基因型分布存在边缘显著差异（P=0.04）。与先前的研究一致，在住院 COVID-19 受试者中检测到携带次要等位基因的频率略高，但无统计学意义。我们得出结论，ABCA3 基因中的常见多态性可能是 SARS-CoV-2 感染易感性的重要预测因素。
