Korea Zoonosis Research Institute, Jeonbuk National University, Iksan 54531, Jeonbuk, Korea.
Department of Bioactive Material Sciences and Institute for Molecular Biology and Genetics, Jeonbuk National University, Jeonju 54896, Jeonbuk, Korea.
Genes (Basel). 2020 Dec 30;12(1):42. doi: 10.3390/genes12010042.
Coronavirus disease 2019 (COVID-19) is a fatal pandemic disease that is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of 13 December, 2020, over 70,000,000 cases and 1,500,000 deaths have been reported over a period of several months; however, the mechanism underlying the pathogenesis of COVID-19 has not been elucidated. To identify the novel risk genetic biomarker for COVID-19, we evaluated the correlation between the case fatality rate of COVID-19 and the genetic polymorphisms of several potential COVID-19-related genes, including interferon-induced transmembrane protein 3 (), the angiotensin I converting enzyme 2 () gene, transmembrane protease, serine 2 (), interleukin 6 (), leucine zipper transcription factor-like protein 1 (), and the genes, in various ethnic groups. We obtained the number of COVID-19 cases and deaths from the World Health Organization (WHO) COVID-19 dashboard and calculated the case fatality rate of each ethnic group. In addition, we obtained the allele distribution of the polymorphisms of the and genes from the 1000 Genomes Project and performed Log-linear regression analysis using SAS version 9.4. We found different COVID-19 case fatality rates in each ethnic group. Notably, we identified a strong correlation between the case fatality rate of COVID-19 and the allele frequency of the rs6598045 single nucleotide polymorphism (SNP) of the gene. To the best of our knowledge, this report is the first to describe a strong correlation between the COVID-19 case fatality rate and the rs6598045 SNP of the gene at the population-level.
新型冠状病毒肺炎（COVID-19）是一种由严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染引起的致命性大流行疾病。截至 2020 年 12 月 13 日，在数月的时间内，已报告超过 7000 万例病例和 150 万例死亡病例；然而，COVID-19 的发病机制尚未阐明。为了确定 COVID-19 的新型风险遗传生物标志物，我们评估了 COVID-19 的病死率与几个潜在的 COVID-19 相关基因的遗传多态性之间的相关性，这些基因包括干扰素诱导跨膜蛋白 3（）、血管紧张素 I 转换酶 2（）基因、跨膜蛋白酶丝氨酸 2（）、白细胞介素 6（）、亮氨酸拉链转录因子样蛋白 1（）和 基因，在不同种族中。我们从世界卫生组织（WHO）COVID-19 数据仪表盘获取 COVID-19 病例和死亡人数，并计算每个种族的病死率。此外，我们从 1000 基因组计划中获得了 基因和 基因多态性的等位基因分布，并使用 SAS 版本 9.4 进行 Log-linear 回归分析。我们发现不同种族的 COVID-19 病死率不同。值得注意的是，我们发现 COVID-19 的病死率与 基因的 rs6598045 单核苷酸多态性（SNP）的等位基因频率之间存在很强的相关性。据我们所知，这是首次在人群水平上描述 COVID-19 的病死率与 基因的 rs6598045 SNP 之间存在很强的相关性。
