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HLA genetic polymorphisms and prognosis of patients with COVID-19.HLA基因多态性与新型冠状病毒肺炎患者的预后
Med Intensiva. 2021 Mar;45(2):96-103. doi: 10.1016/j.medin.2020.08.004. Epub 2020 Sep 6.
2
Effect of polymorphism rs1799752 on protein levels of ACE2, the SARS-CoV-2 entry receptor, in alveolar lung epithelium.多态性rs1799752对肺泡肺上皮细胞中SARS-CoV-2进入受体ACE2蛋白水平的影响。
ERJ Open Res. 2021 Apr 19;7(2). doi: 10.1183/23120541.00940-2020. eCollection 2021 Apr.
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Investigating the ACE2 polymorphisms in COVID-19 susceptibility: An in silico analysis.探究 ACE2 多态性与 COVID-19 易感性的关系：一项计算机分析。
Mol Genet Genomic Med. 2021 Jun;9(6):e1672. doi: 10.1002/mgg3.1672. Epub 2021 Apr 5.
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Dipeptidylpeptidase-4 levels and DPP4 gene polymorphisms in patients with COVID-19. Association with disease and with severity.COVID-19 患者的二肽基肽酶-4 水平和 DPP4 基因多态性。与疾病和严重程度的关系。
Life Sci. 2021 Jul 1;276:119410. doi: 10.1016/j.lfs.2021.119410. Epub 2021 Mar 24.
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Common variants at 21q22.3 locus influence and gene expression and susceptibility to severe COVID-19.21号染色体长臂22.3区域的常见变异影响基因表达及对重症COVID-19的易感性。
iScience. 2021 Apr 23;24(4):102322. doi: 10.1016/j.isci.2021.102322. Epub 2021 Mar 17.
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Association of HLA Class I Genotypes With Severity of Coronavirus Disease-19.人类白细胞抗原 I 类基因型与 2019 冠状病毒病严重程度的关联。
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The effect of ABO blood group and antibody class on the risk of COVID-19 infection and severity of clinical outcomes.ABO 血型和抗体类别对 COVID-19 感染风险和临床结局严重程度的影响。
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Why blood group A individuals are at risk whereas blood group O individuals are protected from SARS-CoV-2 (COVID-19) infection: A hypothesis regarding how the virus invades the human body via ABO(H) blood group-determining carbohydrates.为什么 A 型血个体面临风险，而 O 型血个体则受到 SARS-CoV-2（COVID-19）感染的保护：一种关于病毒如何通过 ABO(H)血型决定的碳水化合物入侵人体的假说。
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宿主基因多态性与新型冠状病毒肺炎感染

Host polymorphisms and COVID-19 infection.

作者信息

Delanghe Joris R, Speeckaert Marijn M

机构信息

Department of Diagnostic Sciences, Ghent University, Ghent, Belgium.

Department of Nephrology, Ghent University Hospital, Ghent, Belgium; Research Foundation-Flanders (FWO), Brussels, Belgium.

出版信息

Adv Clin Chem. 2022;107:41-77. doi: 10.1016/bs.acc.2021.07.002. Epub 2021 Aug 23.

DOI:10.1016/bs.acc.2021.07.002
PMID:35337605
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8381193/
Abstract

Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus, severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). There is growing evidence that host genetics play an important role in COVID-19 severity. Based on current knowledge about the human protein machinery for SARS-CoV-2 entry, the host innate immune response, and virus-host interactions, the potential effects of human genetic polymorphisms, which may contribute to clinical differences in SARS-CoV-2 pathogenesis, may help to determine the individual risk for COVID-19 infection and outcome.

摘要

冠状病毒病（COVID-19）是一种由新发现的冠状病毒——严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的传染病。越来越多的证据表明，宿主基因在COVID-19的严重程度中起着重要作用。基于目前对SARS-CoV-2进入人体的蛋白质机制、宿主固有免疫反应以及病毒与宿主相互作用的了解，人类基因多态性的潜在影响可能有助于确定SARS-CoV-2发病机制中的临床差异，进而有助于确定个体感染COVID-19的风险和预后。