宿主基因多态性与新型冠状病毒肺炎感染
Host polymorphisms and COVID-19 infection.
作者信息
Delanghe Joris R, Speeckaert Marijn M
机构信息
Department of Diagnostic Sciences, Ghent University, Ghent, Belgium.
Department of Nephrology, Ghent University Hospital, Ghent, Belgium; Research Foundation-Flanders (FWO), Brussels, Belgium.
出版信息
Adv Clin Chem. 2022;107:41-77. doi: 10.1016/bs.acc.2021.07.002. Epub 2021 Aug 23.
Abstract
Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus, severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). There is growing evidence that host genetics play an important role in COVID-19 severity. Based on current knowledge about the human protein machinery for SARS-CoV-2 entry, the host innate immune response, and virus-host interactions, the potential effects of human genetic polymorphisms, which may contribute to clinical differences in SARS-CoV-2 pathogenesis, may help to determine the individual risk for COVID-19 infection and outcome.
摘要
冠状病毒病（COVID-19）是一种由新发现的冠状病毒——严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的传染病。越来越多的证据表明，宿主基因在COVID-19的严重程度中起着重要作用。基于目前对SARS-CoV-2进入人体的蛋白质机制、宿主固有免疫反应以及病毒与宿主相互作用的了解，人类基因多态性的潜在影响可能有助于确定SARS-CoV-2发病机制中的临床差异，进而有助于确定个体感染COVID-19的风险和预后。
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