Bogolepova A N, Makhnovich E V, Kovalenko E A, Osinovskaya N A, Beregov M M
Pirogov Russian National Research Medical University, Moscow, Russia.
Federal Center of Brain Research and Neurotechnologies, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2023;123(9):43-51. doi: 10.17116/jnevro202312309143.
To identify the relationship of neuropsychological changes in patients with Alzheimer's disease (AD) and primary open-angle glaucoma (POAG) and to evaluate the results of magnetic resonance (MR)-morphometry in patients with these diseases.
We examined 32 patients (median age 67 [61.25; 76.75] years, 78.1% women) diagnosed with AD and POAG. The patients were divided into the AD group (16) and the POAG group (=16). Complaints and anamnesis were collected for all patients, neurological status and neuropsychological status were assessed. MRI of the brain, followed by morphometry, was performed.
Cognitive impairments (CI) were revealed in patients of both groups. The severity of CI in patients with AD was more pronounced than in patients with POAG (<0.001). Alzheimer's type of CI was detected in both groups. MR-morphometry revealed a decrease in the volume of the left hippocampus, the volume of the right and left amygdala as well as a decrease in the thickness of the right and left entorhinal cortex in the AD group compared with the POAG group (<0.05). A significant decrease in the thickness of the right medial orbitofrontal cortex was found in the POAG group compared with the AD group (<0.05).
In AD and POAG, there is a similarity of the neuropsychological profile, which reflects the neurodegeneration characteristic of these diseases. MRI morphometry requires an assessment of both volumes and thickness of brain structures. A neuroimaging pattern identified in patients with POAG can be regarded as an indicator of the glaucomatous process.
确定阿尔茨海默病（AD）和原发性开角型青光眼（POAG）患者神经心理学变化之间的关系，并评估这些疾病患者的磁共振（MR）形态学测量结果。
我们检查了32例被诊断为AD和POAG的患者（中位年龄67[61.25；76.75]岁，78.1%为女性）。患者被分为AD组（16例）和POAG组（16例）。收集了所有患者的主诉和病史，评估了神经状态和神经心理学状态。进行了脑部MRI检查，随后进行形态学测量。
两组患者均出现认知障碍（CI）。AD患者的CI严重程度比POAG患者更明显（<0.001）。两组均检测到阿尔茨海默型CI。与POAG组相比，AD组的MR形态学测量显示左侧海马体积、左右杏仁核体积减小，以及左右内嗅皮质厚度减小（<0.05）。与AD组相比，POAG组右侧内侧眶额皮质厚度显著减小（<0.05）。
在AD和POAG中，神经心理学特征存在相似性，这反映了这些疾病的神经退行性变特征。MRI形态学测量需要评估脑结构的体积和厚度。在POAG患者中发现的神经影像学模式可被视为青光眼病变的一个指标。
