College of Biological Resources and Food Engineering, Qujing Normal University, Qujing 655011, China.
Maternal and Child Health and Family Planning Service Center of Zhanyi, Zhanyi 655331, China.
J Asian Nat Prod Res. 2024 May;26(5):541-547. doi: 10.1080/10286020.2023.2260749. Epub 2023 Oct 5.
A phytochemical investigation on the 80% EtOH extract of the fruiting bodies of resulted into the isolation of two previously undescribed lanostane triterpenoids, 7,11-dioxo-3-acetyloxy-26,27-dihydroxy-lanosta-8,24-diene () and 7,20-dioxo-3-acetyloxy-1115-dihydroxy-22,23,24,25,26,27-hexanorlanosta-8-ene (), togeher with one known lanostane triterpenoid ganodermanontriol (). Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (HH COSY, HMQC, and HMBC) NMR spectroscopy. All the triterpenoids were evaluated for their antibacterial activities against six pathogenic microorganisms. Compound exhibited some activities against three Gram positive bacteria with MIC values less than 30 μg/ml.
从 子实体的 80%乙醇提取物中进行植物化学研究，分离得到两种以前未描述的羊毛甾烷三萜，7,11-二酮-3-乙酰氧基-26,27-二羟基-羊毛甾-8,24-二烯（）和 7,20-二酮-3-乙酰氧基-1115-二羟基-22,23,24,25,26,27-六去甲羊毛甾-8-烯（），以及一种已知的羊毛甾烷三萜灵芝三醇（）。通过光谱方法，如 1D 和 2D（HH COSY、HMQC 和 HMBC）NMR 光谱，对所有化合物的结构进行了阐明。所有三萜类化合物均进行了抗菌活性评估，针对六种致病性微生物。化合物 对三种革兰氏阳性菌表现出一定的活性，MIC 值小于 30μg/ml。
