Department of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, Delhi, 110017, India.
Division of Pharmacognosy, Department of Pharmacy, Guru Ghasidas Central University, Bilaspur, Chattisgarh, 495009, India.
Naunyn Schmiedebergs Arch Pharmacol. 2024 Apr;397(4):1935-1956. doi: 10.1007/s00210-023-02734-9. Epub 2023 Oct 5.
The plant Acalypha indica L. is a well-known traditional plant belonging to the family Euphorbiaceae. Traditional practices of the plant claim to treat asthma, pneumonia, wound healing, rheumatoid arthritis, bronchitis, and skin disorders. The major phytochemicals reported are cyanogenic glucosides, tannins, coumarins, flavonoid glycosides, fatty acids, and volatile oils. To summarize the anti-inflammatory potential of Acalypha indica extract and its phytochemicals through preclinical studies. The search terms include anti-inflammatory, Acalypha indica, and Acalypha indica extract independently or in combination with pro-inflammatory markers using various databases, including Scopus, Web of Science, PubMed, ProQuest, and Google Scholar. The results of preclinical studies confirm that Acalypha indica exhibits strong anti-inflammatory activity. Most of the experimental studies that have been conducted on plant extract are protein denaturation, human red blood cell membrane stabilization assay, and carrageenan-induced inflammation models. However, the molecular mechanism in these studies is still unclear to demonstrate its anti-inflammatory effects. Acalypha indica possesses anti-inflammatory effects that may be due to the presence of phenolic compounds especially flavonoids present in the Acalypha indica. Thus, further research is needed, to understand mechanistic insights of the plant phytochemicals to represent anti-inflammatory properties.
飞扬草是大戟科（Euphorbiaceae）的一年生草本植物，是一种传统的药用植物，被广泛应用于民间医学。传统医学认为飞扬草可用于治疗哮喘、肺炎、创伤愈合、类风湿性关节炎、支气管炎和皮肤病等疾病。目前已分离得到的主要化学成分包括氰苷类、单宁类、香豆素类、类黄酮苷类、脂肪酸类和挥发油类等。本研究旨在通过文献综述，总结飞扬草提取物及其主要化学成分的抗炎作用及其机制。检索词包括抗炎、飞扬草、飞扬草提取物，分别或联合使用促炎标志物，检索数据库包括 Scopus、Web of Science、PubMed、ProQuest 和 Google Scholar。多项体内外实验结果表明飞扬草提取物具有较强的抗炎活性。目前大多数实验研究主要集中在植物提取物的蛋白变性、人红细胞膜稳定性试验和角叉菜胶诱导的炎症模型等方面，然而其抗炎作用的分子机制仍不清楚。飞扬草的抗炎作用可能与其所含的酚类化合物，尤其是类黄酮有关。因此，需要进一步研究以阐明其抗炎作用的机制。
