Child Health Evaluative Sciences, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada.
Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, ON, Canada.
Can J Public Health. 2024 Feb;115(1):40-52. doi: 10.17269/s41997-023-00817-x. Epub 2023 Oct 5.
To examine factors associated with COVID-19 vaccination (time to vaccination and vaccination status) among healthy young children participating in primary healthcare.
A cohort study was conducted between November 2021 and September 2022 through the TARGet Kids! primary care research network in Toronto, Canada. Sociodemographic information, child and parent health characteristics, parental vaccine beliefs and child COVID-19 vaccine uptake were collected through parent-reported questionnaires. The primary outcome was time to child COVID-19 vaccination, measured as the time between vaccine availability date and parent-reported child COVID-19 vaccination date. Interval-censored proportional hazard models were used.
A total of 267 children age 0 to 13 years were included. The mean child age was 7.6 years, 52.8% (n = 141) were male, 66.5% (n = 141) had mothers of European ethnicity (with missingness), and 68.2% (n = 182) of the children were vaccinated. All parents of vaccinated children had received the COVID-19 vaccination themselves. The rate of vaccination for children was 2% higher with each one-month increase in child age (adjusted HR = 1.02, 95%CI = 1.01-1.03, p < 0.001). Compared to children whose parents had uncertain beliefs, those whose parents had positive beliefs about the importance and safety of COVID-19 vaccination for their children had higher rates of vaccination (adjusted HR = 8.29, 95%CI = 4.25-16.17, p < 0.001; adjusted HR = 5.09, 95%CI = 3.17-8.17, p < 0.001).
Older child age, parental COVID-19 vaccination, and positive parental beliefs about COVID-19 vaccination were statistically significantly associated with COVID-19 vaccination among healthy young children. Our findings may help to inform policies, practices, and research which aim to strengthen parental vaccine confidence and promote child COVID-19 vaccination.
研究参加初级保健的健康幼儿 COVID-19 疫苗接种（接种时间和接种状况）的相关因素。
2021 年 11 月至 2022 年 9 月期间，通过加拿大多伦多的 TARGet Kids! 初级保健研究网络进行了一项队列研究。通过家长报告的问卷收集了社会人口统计学信息、儿童和家长健康特征、父母疫苗信念以及儿童 COVID-19 疫苗接种情况。主要结果是儿童 COVID-19 疫苗接种时间，定义为疫苗可获得日期和家长报告的儿童 COVID-19 疫苗接种日期之间的时间。使用间隔censored 比例风险模型。
共纳入 267 名 0 至 13 岁的儿童。儿童平均年龄为 7.6 岁，52.8%（n=141）为男性，66.5%（n=141）母亲为欧洲裔（缺失），68.2%（n=182）的儿童接种了疫苗。所有接种疫苗儿童的父母都已接种 COVID-19 疫苗。儿童年龄每增加一个月，疫苗接种率就会增加 2%（调整后的 HR=1.02，95%CI=1.01-1.03，p<0.001）。与父母信念不确定的儿童相比，父母对 COVID-19 疫苗对子女的重要性和安全性持积极信念的儿童接种疫苗的比例更高（调整后的 HR=8.29，95%CI=4.25-16.17，p<0.001；调整后的 HR=5.09，95%CI=3.17-8.17，p<0.001）。
儿童年龄较大、父母接种 COVID-19 疫苗以及父母对 COVID-19 疫苗接种的积极信念与健康幼儿 COVID-19 疫苗接种呈统计学显著相关。我们的研究结果可能有助于为旨在增强父母疫苗信心和促进儿童 COVID-19 疫苗接种的政策、实践和研究提供信息。
