Weber W, Gencík A, Müller H
Cancer Detect Prev. 1986;9(5-6):455-8.
Pedigree data were systematically collected from patients with newly diagnosed malignant diseases in hospital outpatient services and private offices in Basel. Special efforts were made to verify every tumor diagnosis. The families of 380 adult cancer patients (greater than 16 years; 160 men and 220 women) were evaluated. The mean number of relatives per family tree was 33 (5.9 first degree) in men and 39 (6.4 first degree) in women. There were 29% of families with one, 11% with two, and 6% with three or more first-degree relatives who had cancer. In 6% of the families there was one or more first-degree relative with cancer of the same site as in the proband. Hereditary cancer syndromes were detected in several families. Fifty-four percent of all families showed no tumor occurrence in first-degree relatives. Our program clearly demonstrates that a carefully obtained family history can lead to the recognition of persons with high cancer risk in oncological practice.
在巴塞尔的医院门诊和私人诊所中，对新诊断出恶性疾病的患者系统地收集了家系数据。为核实每例肿瘤诊断都付出了特别努力。对380名成年癌症患者（年龄大于16岁；男性160名，女性220名）的家族进行了评估。男性每个家系树的亲属平均数量为33名（5.9名一级亲属），女性为39名（6.4名一级亲属）。有29%的家庭有一名患癌的一级亲属，11%的家庭有两名，6%的家庭有三名或更多患癌的一级亲属。在6%的家庭中，有一名或多名一级亲属患与先证者相同部位的癌症。在几个家族中检测到遗传性癌症综合征。所有家庭中有54%在一级亲属中未出现肿瘤。我们的项目清楚地表明，在肿瘤学实践中，仔细获取的家族史能够识别出癌症高风险人群。
