Donshik P C, Cavanagh H D, Boruchoff S A, Dohlman C H
Am J Ophthalmol. 1979 Jun;87(6):823-6. doi: 10.1016/0002-9394(79)90362-3.
We studied results of 124 keratoplasties in 100 keratoconus patients; 61 men and 39 women varying in ages from 11 to 69 years with an average age of 30 years. Twenty-four patients had bilateral grafts with a 27% incidence of rejection, and 76 patients had unilateral grafts with a 13% incidence of rejection (P less than .01). Data analysis of the first year after the graft of first eyes and subsequent years after the graft of first and second eyes, however, revealed a nearly fourfold increase of rejections following second grafts, with a 17% increased chance of rejection for the first graft after the second was implanted. Only two of the bilateral and two of the unilateral grafts were irreversibly lost because of graft reaction. The major complication was the formation of posterior subcapsular cataract, which occurred in approximately 32% of the patients. The final postkeratoplasty visual acuities were significantly improved. In the patients who did not develop a cataract, 86% achieved visual acuity of 6/12 (20/40) or better. In the patients who did develop cataracts, 68% achieved visual acuity of 6/12 (20/40) or better.
我们研究了100例圆锥角膜患者的124次角膜移植结果；其中61例男性和39例女性，年龄从11岁至69岁不等，平均年龄为30岁。24例患者接受了双眼移植，排斥反应发生率为27%，76例患者接受了单眼移植，排斥反应发生率为13%（P小于0.01）。然而，对第一眼移植后的第一年以及第一眼和第二眼移植后的后续年份进行数据分析发现，第二次移植后排斥反应增加了近四倍，第二次移植后第一次移植的排斥几率增加了17%。仅2例双眼移植和2例单眼移植因移植反应而不可逆地失败。主要并发症是后囊下白内障的形成，约32%的患者出现该并发症。角膜移植术后最终视力有显著改善。在未发生白内障的患者中，86%的患者视力达到6/12（20/40）或更好。在发生白内障的患者中，68%的患者视力达到6/12（20/40）或更好。
