Department of Applied Sciences, CEC-Chandigarh Group of Colleges, Landran, Mohali, 140307, Punjab, India.
J Mech Behav Biomed Mater. 2023 Nov;147:106145. doi: 10.1016/j.jmbbm.2023.106145. Epub 2023 Sep 28.
The review paper starts with the introduction to hydrogels along with broad literature survey covering different modes of synthesis including high energy radiation methods. After that, paper covered broad classification of the hydrogels depending upon the basis of their source of origin, method of synthesis, type of cross-linking present and ionic charges on bound groups. Another advanced category response triggered hydrogels, which includes pH, temperature, electro, and light and substrate responsive hydrogels was also studied. Presented paper summarises chemical structure, properties, and synthesis of different kinds of hydrogels. Main focus was given to the preparation super absorbents such as: Semi-interpenetrating networks (semi-IPNs), Interpenetrating networks (IPNs) and cross-linked binary graft copolymers (BGCPs). The weak mechanical properties and easy degradation limit the uses of bio-based -hydrogels in biomedical field. Their properties can be improved through different chemical and physical methods. These methods were also discussed in the current research paper. Also, it includes development of hydrogels as controlled drug delivery devices, as implants and biomaterials to replace malfunctioned body parts along with their use in several other applications listed in the literature. Literature survey on the application of hydrogels in different fields like biomedical, nano-biotechnology, tissue engineering, drug delivery and agriculture was also carried out.
这篇综述论文首先介绍了水凝胶,并广泛调查了不同的合成模式,包括高能辐射方法。然后,本文根据水凝胶的来源、合成方法、交联类型和结合基团的离子电荷对其进行了广泛的分类。还研究了另一种高级类别——响应触发水凝胶,包括 pH、温度、电和光以及基底响应水凝胶。本文总结了不同类型水凝胶的化学结构、性能和合成。重点介绍了制备超吸水性材料,如:半互穿网络(半 IPN)、互穿网络(IPN)和交联二元接枝共聚物(BGCP)。生物基 -水凝胶在生物医学领域的应用受到其机械性能较弱和易降解的限制。可以通过不同的化学和物理方法来改善它们的性能。本文也讨论了这些方法。此外,还介绍了水凝胶作为控制药物释放装置、植入物和生物材料来替代功能失调的身体部位的发展,以及它们在文献中列出的其他几个应用领域的应用。还对水凝胶在生物医学、纳米生物技术、组织工程、药物输送和农业等不同领域的应用进行了文献调查。