Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan 410078, PR China; Cancer Research Institute, School of Basic Medicine, Central South University, Changsha, Hunan 410078, PR China.
Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410078, PR China.
Life Sci. 2023 Nov 15;333:122145. doi: 10.1016/j.lfs.2023.122145. Epub 2023 Oct 4.
Colorectal cancer (CRC) is a lethal malignancy with limited treatment strategies. Accumulating evidence indicates that CRC tumorigenesis, progression and metastasis are intimately associated with circadian clock, an inherent 24-h cycle oscillation of biochemical, physiological functions in almost every eukaryote. In the present review, we summarize the altered expression level of circadian genes in CRC and the prognosis associated with gene abundance switch. We illustrate the function and potential mechanisms of circadian genes in CRC pathogenesis and progression. Moreover, circadian based-therapeutic strategies including chronotherapy, therapeutics targeting potential circadian components, and melatonin treatment in CRC are also highlighted.
结直肠癌（CRC）是一种致命的恶性肿瘤，治疗策略有限。越来越多的证据表明，CRC 的发生、发展和转移与生物钟密切相关，生物钟是几乎所有真核生物中生化、生理功能的固有 24 小时周期波动。在本综述中，我们总结了 CRC 中昼夜节律基因表达水平的改变以及与基因丰度变化相关的预后。我们说明了昼夜节律基因在 CRC 发病机制和进展中的作用和潜在机制。此外，还强调了基于昼夜节律的治疗策略，包括时间治疗、针对潜在昼夜节律成分的治疗以及 CRC 中的褪黑素治疗。
