离散吲哚萜类基因簇之间的功能串扰在. 中
Functional Crosstalk between Discrete Indole Terpenoid Gene Clusters in .
机构信息
Ferrier Research Institute, Victoria University of Wellington, Wellington 6012, New Zealand.
Maurice Wilkins Centre for Molecular Biodiscovery, Victoria University of Wellington, Wellington 6012, New Zealand.
出版信息
Org Lett. 2023 Oct 20;25(41):7470-7475. doi: 10.1021/acs.orglett.3c02412. Epub 2023 Oct 5.
Indole terpenoids make up a large group of secondary metabolites that display an enticing array of bioactivities. While indole diterpene (IDT) and rarely indole sesquiterpene (IST) pathways have been found individually in filamentous fungi, here we show that both cluster types are encoded within the genome of . Through heterologous reconstruction, we demonstrate the cluster encodes for IST biosynthesis and can tailor IDT substrates produced by the cluster.
吲哚萜类化合物构成了一大类次生代谢产物，具有诱人的多种生物活性。虽然在丝状真菌中已经分别发现了吲哚二萜（IDT）和很少的吲哚倍半萜（IST）途径，但在这里我们表明，这两种类型的簇都被编码在 的基因组中。通过异源重建，我们证明了 簇编码 IST 生物合成，并可以调整 簇产生的 IDT 底物。
Zotero 插件