Department of Pharmacy, Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, No. 20,Third Section, Renmin Nan Lu, Chengdu, 610041, Sichuan, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.
Sci Rep. 2023 Oct 5;13(1):16814. doi: 10.1038/s41598-023-43538-4.
We aimed to evaluate the prevalence of medication adherence, assess the association between guardians' mental health and medication adherence for children seen at outpatient department from western China, and identify characteristics associated with nonadherence. We conducted a cross-sectional survey. Participants were recruited by consecutive sampling from the outpatient of the West China Second Hospital from October 2021 to April 2022. The Morisky Medication Adherence Scale (MMAS-8) was used to evaluate patients' medication adherence. A multivariate linear regression model was used to analyze influencing factors. 1206 children with a mean age of 6.02 ± 3.86 years were included. Seventeen percent (208/1206) of patients showed good adherence, 24.7% (298/1206) showed moderate adherence, and 58% (700/1206) showed poor adherence. Thirty-five percent (428/1206) of guardians had anxiety. Factors that influenced medication adherence included anxiety score of guardian (P = 0.030), education level of guardian (P = 0.003), annual household income (P = 0.001), and days the patient is on the medication (P = 0.023). A majority of children seen at outpatient department from West China had low medication adherence, and depression and anxiety among guardians were common. Implementing health education measures will be important for improving medication adherence in future.
我们旨在评估药物依从性的流行率，评估中国西部门诊就诊儿童的监护人心理健康与药物依从性之间的关联，并确定与不依从相关的特征。我们进行了一项横断面调查。参与者通过连续抽样从 2021 年 10 月至 2022 年 4 月的华西第二医院门诊招募。采用 Morisky 药物依从性量表（MMAS-8）评估患者的药物依从性。采用多元线性回归模型分析影响因素。共纳入 1206 名平均年龄为 6.02±3.86 岁的儿童。17%（208/1206）的患者表现出良好的依从性，24.7%（298/1206）表现出中等依从性，58%（700/1206）表现出较差的依从性。35%（428/1206）的监护人有焦虑。影响药物依从性的因素包括监护人的焦虑评分（P=0.030）、监护人的教育水平（P=0.003）、家庭年收入（P=0.001）和患者服药天数（P=0.023）。大多数在中国西部门诊就诊的儿童药物依从性较低，监护人中抑郁和焦虑较为常见。未来实施健康教育措施对于提高药物依从性将很重要。
