Baghdadi Leena R, Alsaiady Manar M
Department of Family and Community Medicine, College of Medicine, King Saud University, Riyadh 11362, Saudi Arabia.
King Khalid University Hospital, King Saud University Medical City, Riyadh 12372, Saudi Arabia.
Children (Basel). 2024 Feb 29;11(3):293. doi: 10.3390/children11030293.
Medication adherence is critical for the treatment and improved outcomes of chronic diseases. However, there is little research on the medication adherence of pediatric dialysis patients in Saudi Arabia. This study examines medication adherence barriers and their relationship to health determinants among Saudi children on dialysis, to enhance treatment success. We conducted a hospital-based, cross-sectional survey of pediatric dialysis patients using a simple random sampling technique. There is a trend of higher medication adherence for peritoneal dialysis patients compared with hemodialysis patients (36.1 ± 12.9 vs. 34.7 ± 8.3, = 0.07). The leading barriers to medication adherence for all patients included being tired of taking the medication (score = 3.0256), not feeling like taking the medicine sometimes (score = 2.7436), bad taste (score = 2.5513), and forgetfulness (score = 2.41). Determinants of health were associated with medication adherence. Lack of education (56.4%) (some children underage for school) and chronic disease requirements (16.7%) were common barriers. After adjusting for the common confounders, the adherence scores increased significantly with increasing patient age (β = 2.378, < 0.001), patients with working parents (β = 8.726, = 0.011), and those living outside Riyadh (β = 19.198, < 0.001). Medication adherence among pediatric dialysis patients is influenced by sociodemographic factors, health systems, and access to care. Evidence-based targeted interventions can increase medication adherence in this group on frequent dialysis. Future efforts should utilize systematic frameworks and digital health technologies to provide quality alternatives to improve medication adherence.
药物依从性对于慢性病的治疗和改善预后至关重要。然而，沙特阿拉伯儿科透析患者的药物依从性研究较少。本研究旨在探讨沙特接受透析治疗儿童的药物依从性障碍及其与健康决定因素的关系，以提高治疗成功率。我们采用简单随机抽样技术，对儿科透析患者进行了一项基于医院的横断面调查。与血液透析患者相比，腹膜透析患者的药物依从性有更高的趋势（36.1±12.9对34.7±8.3，P = 0.07）。所有患者药物依从性的主要障碍包括厌倦服药（得分=3.0256）、有时不想吃药（得分=2.7436）、味道不好（得分=2.5513）和健忘（得分=2.41）。健康决定因素与药物依从性相关。缺乏教育（56.4%）（一些儿童未到上学年龄）和慢性病需求（16.7%）是常见障碍。在调整常见混杂因素后，依从性得分随着患者年龄的增加（β = 2.378，P < 0.001）、父母有工作的患者（β = 8.726，P = 0.011）以及居住在利雅得以外地区的患者（β = 19.198，P < 0.001）而显著增加。儿科透析患者的药物依从性受社会人口统计学因素、卫生系统和医疗服务可及性的影响。基于证据的针对性干预措施可以提高这一频繁透析群体的药物依从性。未来的努力应利用系统框架和数字健康技术，提供高质量的替代方案，以改善药物依从性。
