Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Department of Obstetrics and Gynecology, People's Hospital of Bomi, Nyingchi, Tibet, China.
Front Public Health. 2023 Sep 20;11:1251440. doi: 10.3389/fpubh.2023.1251440. eCollection 2023.
This study aims to address the existing data gap regarding the status of high-risk human papillomavirus (HR-HPV) infection and the distribution of HR-HPV subtypes among women in rural areas of Nyingchi City, Tibet. The research objectives include providing insights for HPV vaccine development.
The research collected data from two rounds of cancer screening conducted among rural women in Nyingchi City, Tibet, from 2019 to 2022. HR-HPV subtype gene detection was performed using the PCR fluorescence method on the collected samples. And then analyzed the HR-HPV infection rate among rural women in Nyingchi City, Tibet, as well as the infection rate of different HR-HPV subtypes and their distribution across different age groups. A comparison was made between the infection rates of women in rural areas outside the Qinghai-Tibet Plateau and those in Nyingchi City.
A total of 15,687 cases included. The overall HR-HPV infection rate among women in rural areas of Nyingchi City, Tibet, was 13.00% (2040/15,687), which was significantly higher than the rate among women in rural areas outside the Qinghai-Tibet Plateau (7.82% (9,249/118,237); = 635.7, < 0.001). The highest HPV infection rate was observed in the 35-39 age group, with a rate of 15.31% (499/3260), which was significantly higher than the rate of 7.22% (1827/25,322) among women in the same age group in rural areas outside the Qinghai-Tibet Plateau ( = 253.00, < 0.001). The lowest HPV infection rate was found in the 50-54 age group, with a rate of 9.69% (246/2540), which was statistically different from the rate of 8.14% (1,604/19,698) among women in the same age group outside the Qinghai-Tibet Plateau ( = 17.68, < 0.001). The top three HR-HPV subtypes among women in rural areas of Nyingchi City, Tibet, were HPV52 (20.15%, 411/2040), HPV16 (12.45%, 254/2040), and HPV58 (11.96%, 244/2040). These findings align with the top three HR-HPV subtypes among women in rural areas outside the Qinghai-Tibet Plateau. Furthermore, the top three HR-HPV subtypes among women aged 35-39, 40-44, and 45-49 in rural areas of Nyingchi City, Tibet, were HPV52, HPV16, and HPV58. In conclusion, the HR-HPV infection rate among women in rural areas of Nyingchi City, Tibet, is significantly higher compared to women in rural areas outside the Qinghai-Tibet Plateau, with consistent patterns observed in the distribution of the top three HR-HPV subtypes between the two regions.
本研究旨在填补目前有关西藏林芝市农村地区高危型人乳头瘤病毒（HR-HPV）感染状况以及 HR-HPV 亚型分布的空白。研究目的包括为 HPV 疫苗的开发提供参考。
研究收集了 2019 年至 2022 年期间在西藏林芝市农村地区进行的两轮癌症筛查数据。采用 PCR 荧光法对采集的样本进行 HR-HPV 亚型基因检测。然后分析了西藏林芝市农村妇女的 HR-HPV 感染率，以及不同 HR-HPV 亚型的感染率及其在不同年龄组的分布。比较了青藏高原以外农村地区和林芝市农村地区妇女的感染率。
共纳入 15687 例。西藏林芝市农村地区妇女 HR-HPV 总感染率为 13.00%（2040/15687），明显高于青藏高原以外农村地区妇女的感染率 7.82%（9249/118237）（ = 635.7，<0.001）。HPV 感染率最高的是 35-39 岁年龄组，为 15.31%（499/3260），明显高于青藏高原以外农村地区同年龄组妇女的 7.22%（1827/25322）（ = 253.00，<0.001）。HPV 感染率最低的是 50-54 岁年龄组，为 9.69%（246/2540），与青藏高原以外农村地区同年龄组妇女的 8.14%（1，604/19698）有统计学差异（ = 17.68，<0.001）。西藏林芝市农村地区妇女 HR-HPV 前三位亚型分别是 HPV52（20.15%，411/2040）、HPV16（12.45%，254/2040）和 HPV58（11.96%，244/2040）。这与青藏高原以外农村地区妇女 HR-HPV 前三位亚型一致。此外，在林芝市农村地区 35-39 岁、40-44 岁和 45-49 岁的妇女中，HR-HPV 前三位亚型也是 HPV52、HPV16 和 HPV58。综上所述，西藏林芝市农村地区妇女的 HR-HPV 感染率明显高于青藏高原以外农村地区，且两地 HR-HPV 前三位亚型的分布模式一致。
