Department of Gynecology and Obstetrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Department of Gynecology and Obstetrics, Shannan Maternal and Child Health Hospital, Shannan, Tibet, People's Republic of China.
Virol J. 2022 Mar 18;19(1):46. doi: 10.1186/s12985-022-01775-5.
Data regarding human papillomavirus (HPV) prevalence and genotype distribution are limited in Shannan City, Tibet Tibetan Autonomous Region, China. The purpose of this study is to provide reliable data for guiding women in Shannan City in cervical cancer screening and HPV vaccine innoculation.
HPV testing was performed on women aged 16-109 years (mean age 44.03 ± 9.25 years) from Shannan City in 2019 and 2020, which was implemented technically by gynecological examination, vaginal discharge smear microscopy, cytology, and HPV detection. The overall prevalence, age-specific prevalence, and genotype distribution were analyzed.
A total of 48,126 women received HPV testing, of which 3929 were detected human papillomavirus. The HPV-positive rate was 8.16% (3929/48,126), and the highest prevalence was in the ≤ 25-year-old age group (12.68%). After the age of 25, the prevalence rate decreased rapidly, and then slowly increased from 7.49% in the 46-55 age group to 9.82% in the ≥ 66 age group, showing a "U-shaped" pattern. The positive prevalence of HPV 16 or 18-only was 1.43%, that of other HPV genotypes except HPV 16 or 18 was 6.39%, and mixed HPV infections including HPV 16 or 18 was 0.34%.
The HPV infection rate in Shannan city is rather low, and the age-specific prevalence of HPV infection presents a "U" curve, suggesting the importance of screening among younger women and the necessity of detection among older women.
西藏自治区山南市的人乳头瘤病毒（HPV）流行率和基因型分布数据有限。本研究的目的是为山南市的女性宫颈癌筛查和 HPV 疫苗接种提供可靠数据。
对 2019 年和 2020 年来自山南市的 16-109 岁（平均年龄 44.03±9.25 岁）的女性进行 HPV 检测，检测技术由妇科检查、阴道分泌物涂片显微镜检查、细胞学和 HPV 检测共同完成。分析了总流行率、年龄特异性流行率和基因型分布。
共有 48126 名女性接受了 HPV 检测，其中 3929 人检测出 HPV。HPV 阳性率为 8.16%（3929/48126），最高流行率出现在≤25 岁年龄组（12.68%）。25 岁以后，阳性率迅速下降，然后从 46-55 岁年龄组的 7.49%缓慢上升到≥66 岁年龄组的 9.82%，呈“U”形模式。HPV16 或 18 型阳性率为 1.43%，除 HPV16 或 18 型以外的其他 HPV 基因型阳性率为 6.39%，HPV16 或 18 型混合感染阳性率为 0.34%。
山南市 HPV 感染率较低，HPV 感染的年龄特异性流行呈“U”形曲线，提示对年轻女性进行筛查的重要性和对老年女性进行检测的必要性。
