Wolff-Trombini Laura, Ceripa Adrien, Moreau Julien, Galinat Hubert, James Chloe, Westbrook Nathalie, Allain Jean-Marc
Université de Bordeaux, UMR1034, Inserm, Biology of Cardiovascular Diseases, Pessac, France.
LMS, CNRS, Ecole Polytechnique, Institut Polytechnique de Paris, Palaiseau, France.
Biomed Opt Express. 2023 Jul 19;14(8):4179-4189. doi: 10.1364/BOE.492669. eCollection 2023 Aug 1.
Hypercoagulability is a pathology that remains difficult to explain today in most cases. It is likely due to a modification of the conditions of polymerization of the fibrin, the main clot component. Using passive microrheology, we measured the mechanical properties of clots and correlated them under the same conditions with structural information obtained with confocal microscopy. We tested our approach with known alterations: an excess of fibrinogen and of coagulation Factor VIII. We observed simultaneously a rigidification and densification of the fibrin network, showing the potential of microrheology for hypercoagulability diagnosis.
高凝状态是一种病理学现象，如今在大多数情况下仍难以解释。这可能是由于主要凝血块成分纤维蛋白的聚合条件发生了改变。我们使用被动微流变学方法测量了凝血块的力学性能，并在相同条件下将其与通过共聚焦显微镜获得的结构信息相关联。我们用已知的改变情况（纤维蛋白原和凝血因子 VIII 过量）来测试我们的方法。我们同时观察到纤维蛋白网络的硬化和致密化，这表明微流变学在高凝状态诊断方面具有潜力。
