接种重组乙型流感病毒神经氨酸酶蛋白疫苗诱导的免疫可在豚鼠中以暴露强度依赖的方式打破病毒传播链。
Immunity induced by vaccination with recombinant influenza B virus neuraminidase protein breaks viral transmission chains in guinea pigs in an exposure intensity-dependent manner.
机构信息
Department of Microbiology, Icahn School of Medicine at Mount Sinai , New York, New York, USA.
Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai , New York, New York, USA.
出版信息
J Virol. 2023 Oct 31;97(10):e0105723. doi: 10.1128/jvi.01057-23. Epub 2023 Oct 6.
Abstract
Vaccines that can slow respiratory virus transmission in the population are urgently needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza virus. Here, we describe how a recombinant neuraminidase-based influenza virus vaccine reduces transmission in vaccinated guinea pigs in an exposure intensity-based manner.
摘要
对于严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）和流感病毒，我们迫切需要能够减缓人群中呼吸道病毒传播的疫苗。在这里，我们描述了基于重组神经氨酸酶的流感病毒疫苗如何以暴露强度为基础方式降低接种疫苗的豚鼠中的传播。
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