Department of Clinical Neuroscience, Division of Insurance Medicine, Karolinska Institutet, Stockholm, Sweden.
Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
JAMA Netw Open. 2023 Oct 2;6(10):e2336848. doi: 10.1001/jamanetworkopen.2023.36848.
Determining whether migrants with nonaffective psychotic disorders (NAPDs) experience poorer outcomes after illness onset is essential to ensure adequate health care provision to these disadvantaged populations.
To compare cumulative hospital days for NAPDs during the first 5 years of illness among refugee, nonrefugee, and second-generation migrants and their Swedish and Danish peers.
DESIGN, SETTING, AND PARTICIPANTS: This was a prospective cohort study of individuals treated for incident NAPDs in inpatient or outpatient settings between January 1, 2006, and December 31, 2013, and followed up for 5 years. This population-based study used Swedish and Danish national registries. Included participants were individuals in Sweden and Denmark, aged 18 to 35 years, treated for incident NAPDs. Data analyses were conducted from November 2022 to August 2023.
Population group (determined according to residency in either country, not both countries), categorized as refugee (migrants whose residence in Sweden or Denmark was registered as refugee status or family reunification with a refugee), nonrefugee (all other individuals born outside Sweden and Denmark), second generation (individuals born in Sweden or Denmark with at least 1 parent born abroad), or native born (individuals born in Sweden or Denmark with both parents born in these countries).
Total hospital days for NAPDs during the first 5 years of illness, analyzed using a hurdle model. Among those ever admitted, total number of admissions and mean admission length were examined.
In total, 7733 individuals in Sweden (mean [SD] age, 26.0 [5.1] years; 4919 male [63.6%]) and 8747 in Denmark (mean [SD] age 24.8 [5.0] years; 5324 male [60.9%]) were followed up for 5 years or until death or emigration. After adjusting for a range of sociodemographic and clinical factors, the odds of experiencing any hospital days for NAPD were significantly higher among migrant groups compared with their native-born peers (Sweden: second generation, odds ratio [OR], 1.17; 95% CI, 1.03-1.33; P = .01; nonrefugee migrant, OR, 1.45; 95% CI, 1.21-1.73; P < .001; refugee, OR, 1.25; 95% CI, 1.06-1.47; P = .009; Denmark: second generation, OR, 1.21; 95% CI, 1.05-1.40; P = .01; nonrefugee migrant, OR, 1.33; 95% CI, 1.14-1.55; P < .001). These odds were highest among nonrefugee (Sweden: OR, 2.53; 95% CI, 1.59-4.03; P < .001; Denmark: OR, 2.61; 95% CI, 1.70-4.01; P < .001) and refugee (Sweden: OR, 1.96; 95% CI, 1.43-2.69; P < .001; Denmark: OR, 2.14; 95% CI, 1.42-3.21; P < .001) migrants from Africa and those who had arrived within 3 to 5 years (Sweden: nonrefugee migrants, OR, 1.93; 95% CI, 1.26-2.95; P = .002; refugees, OR, 2.38; 95% CI, 1.46-3.88; P < .001; Denmark: nonrefugee migrants, OR, 1.66; 95% CI, 0.96-2.85; P = .07; refugees, OR, 3.40; 95% CI, 1.13-10.17; P = .03). Among those ever hospitalized, refugees in both countries (Sweden, incidence rate ratio [IRR], 1.30; 95% CI, 1.12-1.51; P < .001; Denmark, IRR, 1.47; 95% CI, 1.24-1.75; P < .001) and second-generation migrants in Denmark (IRR, 1.22; 95% CI, 1.07-1.39; P = .003) experienced more days hospitalized for NAPDs than native-born individuals.
In this prospective cohort study of individuals with NAPDs, results suggest that refugee, nonrefugee, and second-generation migrants experience more days hospitalized for these disorders than their native-born peers. Patterns were consistent across 2 countries with different models of psychosis care and immigration and integration policies.
确定非情感性精神病障碍 (NAPD) 患者在发病后是否预后更差对于确保为这些弱势群体提供足够的医疗保健至关重要。
比较难民、非难民和第二代移民以及他们的瑞典和丹麦同龄人在 NAPD 发病的前 5 年内的累积住院天数。
设计、地点和参与者:这是一项对 2006 年 1 月 1 日至 2013 年 12 月 31 日期间在住院或门诊环境中接受新发病 NAPD 治疗的个体进行的前瞻性队列研究,并随访 5 年。这项基于人群的研究使用了瑞典和丹麦的国家登记处。包括的参与者为瑞典和丹麦的 18 至 35 岁、患有新发 NAPD 的个体。数据分析于 2022 年 11 月至 2023 年 8 月进行。
人群群体(根据在两国中的居住情况确定,而非两国均居住),分为难民(居住在瑞典或丹麦的移民身份登记为难民或家庭团聚)、非难民(出生在瑞典和丹麦以外的所有人)、第二代(在瑞典或丹麦出生的至少有 1 位父母出生在国外的个体)或本地出生(在瑞典或丹麦出生且父母双方均出生在这些国家的个体)。
NAPD 发病的前 5 年内的总住院天数,使用障碍模型进行分析。在曾住院的患者中,检查了总住院人数和平均住院时间。
在瑞典(平均[SD]年龄,26.0[5.1]岁;4919 名男性[63.6%])和丹麦(平均[SD]年龄 24.8[5.0]岁;5324 名男性[60.9%])共随访 5 年或直至死亡或移民。在调整了一系列社会人口学和临床因素后,与本地出生的同龄人相比,移民群体出现任何 NAPD 住院天数的可能性显著更高(瑞典:第二代,优势比[OR],1.17;95%CI,1.03-1.33;P =.01;非难民移民,OR,1.45;95%CI,1.21-1.73;P <.001;难民,OR,1.25;95%CI,1.06-1.47;P =.009;丹麦:第二代,OR,1.21;95%CI,1.05-1.40;P =.01;非难民移民,OR,1.33;95%CI,1.14-1.55;P <.001)。在非难民(瑞典:OR,2.53;95%CI,1.59-4.03;P <.001;丹麦:OR,2.61;95%CI,1.70-4.01;P <.001)和难民(瑞典:OR,1.96;95%CI,1.43-2.69;P <.001;丹麦:OR,2.14;95%CI,1.42-3.21;P <.001)移民中,这些优势最高,这些移民来自非洲,并且在 3 至 5 年内抵达(瑞典:非难民移民,OR,1.93;95%CI,1.26-2.95;P =.002;难民,OR,2.38;95%CI,1.46-3.88;P <.001;丹麦:非难民移民,OR,1.66;95%CI,0.96-2.85;P =.07;难民,OR,3.40;95%CI,1.13-10.17;P =.03)。在曾住院的患者中,两国(瑞典,发病率比[IRR],1.30;95%CI,1.12-1.51;P <.001;丹麦,IRR,1.47;95%CI,1.24-1.75;P <.001)和丹麦(IRR,1.22;95%CI,1.07-1.39;P =.003)的难民和第二代移民经历了更多的 NAPD 住院天数。
在这项对 NAPD 患者的前瞻性队列研究中,结果表明难民、非难民和第二代移民比其本地出生的同龄人住院治疗这些疾病的天数更多。这些模式在具有不同精神病治疗模式和移民融合政策的两个国家中是一致的。