Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan 611130, P. R. China.
J Agric Food Chem. 2023 Oct 18;71(41):15331-15340. doi: 10.1021/acs.jafc.3c01163. Epub 2023 Oct 6.
This study investigated the effects of dietary supplementation with taurine (TAU) on the meat quality, muscle fiber type, and mitochondrial function of finishing pigs. The results demonstrated that TAU significantly increased the * value while decreasing *, *, and drip loss and drip loss in the (LD) muscle. Dietary supplemented with TAU reduced the content of lactate and the glycolytic potential (GP) in the LD muscle. Dietary supplemented with TAU enhanced the oxidative fiber-related gene expression as well as increased succinic dehydrogenase and malate dehydrogenase activities while reducing lactate dehydrogenase activity. Furthermore, dietary supplementation with TAU increased the contents of mtDNA and ATP and mitochondrial function-related gene expression. Moreover, TAU enhanced the mRNA expressions of calcineurin () and nuclear factor of activated T cells c1 () and protein expressions of CNA and NFATc1. The results indicate that dietary TAU supplementation improves meat quality and mitochondrial biogenesis and function and promotes muscle fiber-type conversion from the glycolytic fiber to the oxidative fiber via the CaN/NFATc1 pathway.
本研究探讨了牛磺酸（TAU）膳食补充对育肥猪肉质、肌纤维类型和线粒体功能的影响。结果表明，TAU 显著增加了值，同时降低了、*、滴水损失和背最长肌（LD）的滴水损失。TAU 日粮补充降低了 LD 肌肉中乳酸和糖酵解潜能（GP）的含量。TAU 日粮补充增强了与氧化纤维相关的基因表达，同时提高了琥珀酸脱氢酶和苹果酸脱氢酶活性，降低了乳酸脱氢酶活性。此外，TAU 增加了 mtDNA 和 ATP 的含量以及与线粒体功能相关的基因表达。此外，TAU 增强了钙调神经磷酸酶（）和活化 T 细胞核因子 c1（）的 mRNA 表达，以及钙调神经磷酸酶 A （CNA）和 NFATc1 的蛋白表达。结果表明，TAU 日粮补充通过钙调神经磷酸酶/NFATc1 通路改善肉质和线粒体生物发生和功能，并促进从糖酵解纤维向氧化纤维的肌纤维类型转换。
