香豆素的致敏能力（I）。

The sensitizing capacity of coumarins (I).

作者信息

Hausen B M, Schmieder M

出版信息

Contact Dermatitis. 1986 Sep;15(3):157-63. doi: 10.1111/j.1600-0536.1986.tb01317.x.

DOI:10.1111/j.1600-0536.1986.tb01317.x

Abstract

10 coumarins used in perfumery, cosmetics and ointments, have been investigated by 2 different methods to determine their sensitizing capacity. Only 1 of the compounds, 4-methyl-esculetin, which serves as a sunscreen agent, was found to be a weak sensitizer. All other coumarins were negative. It is assumed that this dihydroxycoumarin becomes a sensitizer when it is enzymically oxidized to the corresponding orthoquinone in the skin.

摘要

对用于香料、化妆品和药膏中的10种香豆素，采用2种不同方法研究了它们的致敏能力。仅发现用作防晒剂的化合物之一4-甲基七叶亭是一种弱致敏剂。所有其他香豆素均呈阴性。据推测，这种二羟基香豆素在皮肤中经酶氧化成相应的邻醌时会成为致敏剂。