Department of Mathematics and Programs in Neuroscience and Molecular Biophysics, Florida State University, Tallahassee, FL, United States.
Centre for Systems Modeling and Quantitative Biomedicine, University of Birmingham, United Kingdom.
Math Biosci. 2023 Nov;365:109085. doi: 10.1016/j.mbs.2023.109085. Epub 2023 Oct 4.
Electrical bursting oscillations in the β-cells of pancreatic islets have been a focus of investigation for more than fifty years. This has been aided by mathematical models, which are descendants of the pioneering Chay-Keizer model. This article describes the key biophysical and mathematical elements of this model, and then describes the path forward from there to the Integrated Oscillator Model (IOM). It is both a history and a deconstruction of the IOM that describes the various elements that have been added to the model over time, and the motivation for adding them. Finally, the article is a celebration of the 40th anniversary of the publication of the Chay-Keizer model.
胰腺胰岛β细胞的电爆发振荡已经成为五十多年来的研究焦点。这得益于数学模型，这些模型是开创性的 Chay-Keizer 模型的后代。本文描述了该模型的关键生物物理和数学要素，然后从那里描述了通向集成振荡器模型（IOM）的路径。这既是对 IOM 的历史和解构，描述了随着时间的推移添加到模型中的各种元素，以及添加它们的动机。最后，本文庆祝了 Chay-Keizer 模型发表 40 周年。
