School of Public Health, Fudan University, Shanghai, 200032, China; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 999077, Hong Kong, China.
School of Social Development and Public Policy, Fudan University, Shanghai, 200433, China; Fudan University Center for Population and Development Policy Studies, Fudan University, Shanghai, 200433, China; Fudan Institute on Ageing, Fudan University, Shanghai, 200433, China.
Chemosphere. 2023 Dec;344:140356. doi: 10.1016/j.chemosphere.2023.140356. Epub 2023 Oct 4.
Little is known about the association between air pollution exposure and sarcopenia in Asia. We aimed to investigate the associations of indoor solid fuel use and long-term exposure to ambient fine particulate matter (PM) with sarcopenia in China.
Using a nationally population-representative study, 12,723 participants aged at least 45 years across 125 cities from the China Health and Retirement Longitudinal Study were enrolled in 2011, and further 3110 participants were followed up until 2013. Sarcopenia status was classified according to the Asian Working Group for Sarcopenia 2019 criteria. Household fuel types used for heating and cooking were assessed using a standard questionnaire. Ambient annual PM was estimated using satellite-based spatiotemporal models. Multinomial logistic regression as well as the multiplicative interaction and additive interaction analysis were used to explore the associations of indoor solid fuel and ambient PM with different status of sarcopenia.
Of the 12,723 participants, 6071 (47.7%) were men. In the cross-sectional analyses, compared with clean fuel, using solid fuel for heating and cooking, separately or simultaneously, was significantly associated with a higher risk of both possible sarcopenia and sarcopenia. Each 10 μg/m increment of PM was positively related to possible sarcopenia (adjusted odds ratio, [aOR] 1.04, 1.02-1.07) and sarcopenia (1.06, 1.01-1.12). We found a significant interaction between solid fuel use for heating and ambient PM exposure with possible sarcopenia. During a two-year follow-up, solid fuel use was associated with incident possible sarcopenia (aOR 1.59, 1.17-2.15). These associations did not differ by sex and age, while participants living in a house with poor cleanliness might have a higher risk of sarcopenia.
Indoor solid fuel use and long-term exposure to ambient PM were associated with a higher risk of sarcopenia among Chinese adults. These findings provide implications for promoting healthy aging by reducing air pollution.
亚洲地区有关空气污染暴露与肌肉减少症之间关联的信息较少。我们旨在研究室内固体燃料使用和长期暴露于环境细颗粒物（PM）与中国肌肉减少症之间的关联。
我们使用一项具有全国代表性的研究，共纳入了 2011 年来自全国 125 个城市的至少 45 岁的 12723 名参与者，并在 2013 年对其中的 3110 名参与者进行了随访。根据 2019 年亚洲肌肉减少症工作组的标准，对肌肉减少症的状态进行了分类。使用标准问卷评估了用于取暖和烹饪的家用燃料类型。使用基于卫星的时空模型来估算环境年平均 PM。使用多项逻辑回归以及乘法交互和加法交互分析来探讨室内固体燃料和环境 PM 与不同程度肌肉减少症之间的关联。
在 12723 名参与者中，6071 名（47.7%）为男性。在横断面分析中，与清洁燃料相比，分别或同时使用固体燃料取暖和烹饪与较高的两种可能的肌肉减少症和肌肉减少症风险显著相关。PM 每增加 10μg/m，两种可能的肌肉减少症（调整后的优势比 [aOR] 1.04，1.02-1.07）和肌肉减少症（1.06，1.01-1.12）的风险均呈正相关。我们发现固体燃料取暖的使用与环境 PM 暴露之间存在显著的交互作用，与可能的肌肉减少症相关。在为期两年的随访中，固体燃料的使用与新发生的可能的肌肉减少症相关（aOR 1.59，1.17-2.15）。这些关联在性别和年龄上没有差异，而居住在卫生条件较差的房屋中的参与者可能面临更高的肌肉减少症风险。
室内固体燃料的使用和长期暴露于环境 PM 与中国成年人的肌肉减少症风险增加有关。这些发现为通过减少空气污染来促进健康老龄化提供了启示。
