Guan Yong-Mei, Zhao Shi-Chun, Li Qiong, Chen Li-Hua, Wang Fei, Dong Huan-Huan, Wang Fang, Chen Xiao-Fan, Zhang Hua, Zhu Wei-Feng
Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine Nanchang 330004, China.
School of Pharmacy, Jiangxi University of Chinese Medicine Nanchang 330004, China.
Zhongguo Zhong Yao Za Zhi. 2023 Sep;48(18):4908-4918. doi: 10.19540/j.cnki.cjcmm.20230517.301.
Currently, the gut-organ axis has become a hot research topic. As increasing attention has been paid to the role of gut microbiota in the health of organs, the complex and integrated dialogue mechanism between the gastrointestinal tract and the associated microbiota has been demonstrated in more and more studies. Skin as the largest organ in the human body serves as the primary barrier protecting the human body from damage. The proposal of the gut-skin axis has established a bidirectional link between the gut and the skin. The disturbance of gut microbiota can lead to the occurrence of skin diseases, the mechanism of which is complex and may involve multiple pathways in immunity, metabolism, and internal secretion. According to the theory of traditional Chinese medicine(TCM), the connection between the intestine and the skin can be established through the lung, and the interior disorders will definitely cause symptoms on the exterior. This paper reviews the research progress in the gut-skin axis and its correlation with TCM theory and provides ideas and a basis for cli-nical treatment and drug development of skin and intestinal diseases.
目前，肠-器官轴已成为一个热门研究课题。随着肠道微生物群在器官健康中的作用受到越来越多的关注，胃肠道与相关微生物群之间复杂而综合的对话机制在越来越多的研究中得到了证实。皮肤作为人体最大的器官，是保护人体免受损伤的主要屏障。肠-皮肤轴的提出在肠道和皮肤之间建立了双向联系。肠道微生物群的紊乱可导致皮肤病的发生，其机制复杂，可能涉及免疫、代谢和内分泌等多种途径。根据中医理论，肠与皮肤之间可通过肺建立联系，内有病变必然会在体表出现症状。本文综述了肠-皮肤轴的研究进展及其与中医理论的相关性，为皮肤和肠道疾病的临床治疗及药物研发提供思路和依据。
