Chang Guan-Hua, Zhang Lu, Cui Jie, Wang Wen-Quan, Hou Jun-Ling
Beijing Wehand-Bio Pharmaceutical Co.,Ltd. Beijing 102629,China School of Chinese Materia Medica,Beijing University of Chinese Medicine Beijing 102488,China.
School of Chinese Materia Medica,Beijing University of Chinese Medicine Beijing 102488,China.
Zhongguo Zhong Yao Za Zhi. 2023 Aug;48(16):4413-4420. doi: 10.19540/j.cnki.cjcmm.20230427.202.
The present study investigated the chemical constituents from the aerial parts of Glycyrrhiza uralensis. The ethanol extract of the aerial parts of G. uralensis was separated and purified by different column chromatographies such as macroporous resin, silica gel, and Sephadex LH-20, and through preparative HPLC and recrystallization. Thirteen compounds were isolated and identified as(2S)-6-[(Z)-3-hydroxymethyl-2-butenyl]-5,7,3'-trihydroxy-4'-methoxy-dihydroflavanone(1),(2S)-8-[(E)-3-hydroxymethyl-2-butenyl]-5,7,3',5'-tetrahydroxy-dihydroflavanone(2), α,α'-dihydro-5,4'-dihydroxy-3-acetoxy-2-isopentenylstilbene(3), 6-prenylquercetin(4), 6-prenylquercetin-3-methyl ether(5), formononetin(6), 3,3'-dimethylquercetin(7), chrysoeriol(8), diosmetin(9),(10E,12Z,14E)-9,16-dioxooctadec-10,12,14-trienoic acid(10), 5,7,3',4'-tetrahydroxy-6-prenyl-dihydroflavanone(11), naringenin(12), dibutylphthalate(13). Compounds 1-3 are new compounds, and compounds 10 and 13 are isolated from aerial parts of this plant for the first time.
本研究对甘草地上部分的化学成分进行了研究。甘草地上部分的乙醇提取物通过大孔树脂、硅胶、葡聚糖凝胶LH - 20等不同柱色谱法，以及制备型高效液相色谱法和重结晶进行分离纯化。分离并鉴定出13种化合物，分别为(2S)-6-[(Z)-3-羟甲基-2-丁烯基]-5,7,3'-三羟基-4'-甲氧基二氢黄酮(1)、(2S)-8-[(E)-3-羟甲基-2-丁烯基]-5,7,3',5'-四羟基二氢黄酮(2)、α,α'-二氢-5,4'-二羟基-3-乙酰氧基-2-异戊烯基芪(3)、6-异戊烯基槲皮素(4)、6-异戊烯基槲皮素-3-甲醚(5)、芒柄花素(6)、3,3'-二甲基槲皮素(7)、 Chrysoeriol(8)、香叶木素(9)、(10E,12Z,14E)-9,16-二氧代十八碳-10,12,14-三烯酸(10)、5,7,3',4'-四羟基-6-异戊烯基二氢黄酮(11)、柚皮素(12)、邻苯二甲酸二丁酯(13)。化合物1 - 3为新化合物，化合物10和13首次从该植物地上部分分离得到。
