Shang Mengqing, Hou Yanyan, Gu Yue, Li Haiyan, Zhen Hualong, Jiang Minmin, Zhu Beibei, Tao Fangbiao
School of Public Health, Anhui Medical University, Hefei 230032, China Key Laboratory of Population Health Across Life Cycle, Ministry of Education, Hefei 230032, China Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei 230032, China.
School of Public Health, Anhui Medical University, Hefei 230032, China Key Laboratory of Population Health Across Life Cycle, Ministry of Education, Hefei 230032, China.
Wei Sheng Yan Jiu. 2023 Sep;52(5):732-739. doi: 10.19813/j.cnki.weishengyanjiu.2023.05.008.
To explore the independent and combined effects of smoking and passive smoking during pregnancy on maternal depression, anxiety and depressive anxiety comorbidities.
From August 2020 to February 2022, women who underwent 42-day postpartum examination in Changfeng Women's Center and Shuangfeng Hospital of Hefei were recruited. Their depression and anxiety symptoms were assessed using EPDS Scale and GAD Scale, respectively, and smoking and passive smoking status during pregnancy were collected. Multivariate Logistic regression was used to analyze the independent and combined effects of smoking and passive smoking during pregnancy on postpartum depression, anxiety and depression and anxiety comorbidities.
A total of 2 447 parturients were included, whose mean age was(29.23±4.20) years old.58.6% of parturients lived in urban areas.97.2% parturients had unassisted reproduction and 73.5% pregnancy intention was spontaneous. Among them, 362(14.8%) had depression, 523(21.4%) had anxiety, and 270(11.0%) had depression and anxiety comorbidities. In an independent analysis of effects, maternal smoking during pregnancy was statistically associated with postpartum depression(OR=3.86, 95%CI 2.37-6.28), anxiety(OR =2.58, 95%CI 1.60-4.17) and depressive anxiety comorbidity(OR = 3.34, 95%CI 2.00-5.71). Maternal passive smoking during pregnancy was also positively associated with the risk of postpartum depression(OR = 1.56, 95%CI 2.00-5.71), anxiety(OR=1.71, 95%CI 1.24-2.37) and depression and anxiety comorbidities(OR = 1.52, 95%CI 1.02-2.28), and the higher the frequency of exposure to passive smoking, the higher risk of depression, anxiety, and depressive and anxiety comorbidities. No interaction between smoking during pregnancy and passive smoking exposure on postpartum depression(RERI = 0.69, 95%CI-4.62-6.00; AP = 10.84, 95%CI-73.37-95.04; S= 0.58, 95%CI 0.02-15.18), anxiety(RERI=0.27, 95%CI 0.05-0.49; AP=4.02, 95%CI-0.52-8.57; S=0.78, 95%CI 0.64-0.94) and depression and anxiety comorbidities(RERI = 0.07, 95%CI-0.25-0.39; AP=1.74, 95%CI-6.03-9.52; S=0.93, 95%CI 0.68-1.27)was observed.
Both smoking and passive smoking during pregnancy were positively associated with the risk of postpartum depression, anxiety and depressive anxiety comorbidity.
探讨孕期吸烟和被动吸烟对产妇抑郁、焦虑及抑郁焦虑共病的独立及联合影响。
选取2020年8月至2022年2月在合肥长丰女子中心和双凤医院接受产后42天检查的女性。分别采用爱丁堡产后抑郁量表（EPDS）和广泛性焦虑量表（GAD）评估其抑郁和焦虑症状，并收集孕期吸烟和被动吸烟情况。采用多因素Logistic回归分析孕期吸烟和被动吸烟对产后抑郁、焦虑及抑郁焦虑共病的独立及联合影响。
共纳入2447例产妇，平均年龄（29.23±4.20）岁。58.6%的产妇居住在城市。97.2%的产妇为自然受孕，73.5%的妊娠意愿为自然妊娠。其中，362例（14.8%）有抑郁，523例（21.4%）有焦虑，270例（11.0%）有抑郁焦虑共病。在独立效应分析中，孕期母亲吸烟与产后抑郁（OR=3.86，95%CI 2.37-6.28）、焦虑（OR =2.58，95%CI 1.60-4.17）及抑郁焦虑共病（OR = 3.34，95%CI 2.00-5.71）在统计学上相关。孕期母亲被动吸烟也与产后抑郁（OR = 1.56，95%CI 2.00-5.71）、焦虑（OR=1.71，95%CI 1.24-2.37）及抑郁焦虑共病（OR = 1.52，95%CI 1.02-2.28）风险呈正相关，且被动吸烟暴露频率越高，抑郁、焦虑及抑郁焦虑共病风险越高。未观察到孕期吸烟与被动吸烟暴露对产后抑郁（RERI = 0.
