Department of Learning, Informatics, Management and Ethics (LIME), Karolinska Institutet, Stockholm, Sweden; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Fertil Steril. 2017 Aug;108(2):325-332. doi: 10.1016/j.fertnstert.2017.06.006. Epub 2017 Jun 23.
To study whether conception by means of in vitro fertilization (IVF) is associated with maternal depressive symptoms during pregnancy or postpartum.
Longitudinal observational study.
University hospital.
PATIENT(S): A total of 3,283 women with singleton pregnancies receiving antenatal care and delivering in Uppsala from 2010 to 2015.
INTERVENTION(S): A web-based self-administered structured questionnaire including sociodemographic, clinical and pregnancy-related items, and the Edinburgh Postnatal Depression Scale (EPDS) was delivered at 17 and 32 gestational weeks and at 6 weeks and 6 months postpartum.
MAIN OUTCOME MEASURE(S): Prevalence of significant depressive symptoms (EPDS ≥12) and EPDS scores.
RESULT(S): A total of 167 women (5%) had conceived via IVF and 3,116 (95%) had a spontaneous pregnancy. IVF mothers were more frequently ≥35 years of age (46.1% vs. 22.6%) and primiparous (71.7% vs. 49.9%) and had a higher cesarean delivery rate (22.4% vs. 14.2%). Demographic and clinical characteristics were otherwise similar between the two groups. Significant depressive symptoms were reported by 12.8%, 12.4%, 13.8%, and 11.9% of women at 17 and 32 gestational weeks and 6 weeks and 6 months postpartum, respectively. The prevalence of depressive symptoms and the EPDS scores during pregnancy and postpartum were similar between women conceiving spontaneously or through IVF. The mode of conception was not associated with significant depressive symptoms at any time point, even when adjusting for several possible confounders in multivariable logistic regression analysis.
CONCLUSION(S): Despite the psychologic distress characterizing subfertility and its treatment, conception by means of IVF is not associated with maternal depressive symptoms during pregnancy or postpartum.
研究体外受精（IVF）受孕是否与孕期或产后的产妇抑郁症状相关。
纵向观察性研究。
大学医院。
2010 年至 2015 年期间在乌普萨拉接受产前护理并分娩的 3283 名单胎妊娠妇女。
在妊娠 17 周和 32 周及产后 6 周和 6 个月时，通过网络进行自我管理的结构化问卷，内容包括社会人口学、临床和妊娠相关项目以及爱丁堡产后抑郁量表（EPDS）。
显著抑郁症状（EPDS≥12）和 EPDS 评分的发生率。
共有 167 名女性（5%）通过 IVF 受孕，3116 名女性（95%）为自然受孕。IVF 组母亲年龄较大（≥35 岁者占 46.1%比 22.6%）、初产妇比例较高（71.7%比 49.9%）、剖宫产率较高（22.4%比 14.2%）。两组在其他人口统计学和临床特征方面相似。分别有 12.8%、12.4%、13.8%和 11.9%的女性在妊娠 17 周和 32 周、产后 6 周和 6 个月时报告有显著抑郁症状。自然受孕和 IVF 受孕的女性在孕期和产后的抑郁症状发生率和 EPDS 评分相似。即使在多变量逻辑回归分析中调整了几个可能的混杂因素，受孕方式也与任何时间点的显著抑郁症状无关。
尽管不孕及其治疗会导致心理困扰，但通过 IVF 受孕与孕期或产后的产妇抑郁症状无关。
