Max Perutz Labs, University of Vienna and Medical University of Vienna, Vienna Biocenter Campus (VBC), Dr. Bohr-Gasse 9/3, 1030 Vienna, Austria; Vienna BioCenter PhD Program, Doctoral School of the University of Vienna and Medical University of Vienna, A-1030 Vienna, Austria.
Max Perutz Labs, University of Vienna and Medical University of Vienna, Vienna Biocenter Campus (VBC), Dr. Bohr-Gasse 9/3, 1030 Vienna, Austria.
Curr Opin Cell Biol. 2023 Dec;85:102251. doi: 10.1016/j.ceb.2023.102251. Epub 2023 Oct 5.
Nuclear pore complexes (NPCs) mediate the bidirectional transport of cargo across the nuclear envelope (NE). NPCs are also membrane remodeling machines with a capacity to curve and fuse the membranes of the NE. However, little is known about the interplay of NPCs and lipids at a mechanistic level. A full understanding of NPC structure and function needs to encompass how the NPC shapes membranes and is itself shaped by lipids. Here we attempt to connect recent findings in NPC research with the broader field of membrane biochemistry to illustrate how an interplay between NPCs and lipids may facilitate the conformational plasticity of NPCs and the generation of a unique pore membrane topology. We highlight the need to better understand the NPC's lipid environment and outline experimental avenues towards that goal.
核孔复合体（NPC）介导物质在核膜（NE）的双向运输。NPC 也是一种膜重塑机器，具有弯曲和融合 NE 膜的能力。然而，对于 NPC 和脂质在机制水平上的相互作用，我们知之甚少。要全面了解 NPC 的结构和功能，就需要包括 NPC 如何塑造膜以及自身如何被脂质塑造。在这里，我们试图将 NPC 研究的最新发现与更广泛的膜生物化学领域联系起来，说明 NPC 和脂质之间的相互作用如何促进 NPC 的构象灵活性和独特的孔膜拓扑结构的产生。我们强调需要更好地了解 NPC 的脂质环境，并概述实现这一目标的实验途径。
