Zeng Z, Peng Y Z, Yuan Z Q
State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing 400038, China.
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2023 Jul 20;39(7):679-684. doi: 10.3760/cma.j.cn501225-20230320-00086.
Sepsis is a life-threatening condition for patients. Biomarkers can be used for the diagnosis, treatment, and prognostic assessment of sepsis. In recent years, new biomarkers for sepsis have been discovered, and more than 250 biomarkers have been identified so far. The complexity of the sepsis process and the increased sensitivity of various detection techniques will lead to the emergence of new biomarkers. However, there is still a lack of specific diagnostic biomarkers and effective therapeutic approaches for sepsis in clinical practice. Therefore, the search for reliable biomarkers and the evaluation of the role of biomarkers in sepsis will undoubtedly aid in clinical decision-making. This article reviews the advances on research of sepsis biomarkers in order to improve understanding of current biomarkers of sepsis, and provide reference for the application of biomarkers in clinical diagnosis, treatment, and prognosis of sepsis.
脓毒症对患者来说是一种危及生命的病症。生物标志物可用于脓毒症的诊断、治疗及预后评估。近年来，已发现用于脓毒症的新型生物标志物，迄今已鉴定出250多种生物标志物。脓毒症过程的复杂性以及各种检测技术敏感性的提高将导致新生物标志物的出现。然而，临床实践中仍缺乏用于脓毒症的特异性诊断生物标志物和有效的治疗方法。因此，寻找可靠的生物标志物并评估生物标志物在脓毒症中的作用无疑将有助于临床决策。本文综述了脓毒症生物标志物的研究进展，以增进对当前脓毒症生物标志物的了解，并为生物标志物在脓毒症临床诊断、治疗及预后中的应用提供参考。
