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The chicken or the egg: The role of IL-6 in pediatric obese and allergen-exposed asthma.先有鸡还是先有蛋：白细胞介素-6在儿童肥胖及暴露于过敏原的哮喘中的作用
J Allergy Clin Immunol. 2023 Dec;152(6):1420-1422. doi: 10.1016/j.jaci.2023.09.037. Epub 2023 Oct 6.
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High plasma IL-6 levels may enhance the adverse effects of mouse allergen exposure in urban schools on asthma morbidity in children.高血浆白细胞介素 6 水平可能会增强城市学校中老鼠过敏原暴露对儿童哮喘发病率的不良影响。
J Allergy Clin Immunol. 2023 Dec;152(6):1677-1682. doi: 10.1016/j.jaci.2023.06.027. Epub 2023 Aug 3.
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Chicken serum albumin (Gal d 5*) is a partially heat-labile inhalant and food allergen implicated in the bird-egg syndrome.鸡血清白蛋白（Gal d 5*）是一种部分热不稳定的吸入性和食物过敏原，与鸟蛋综合征有关。
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Children (Basel). 2022 Sep 24;9(10):1462. doi: 10.3390/children9101462.

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High Interleukin (IL)-6 is Associated with Lower Lung Function and Increased Likelihood of Metabolic Dysfunction in Asthma.高白细胞介素（IL）-6与哮喘患者较低的肺功能及代谢功能障碍可能性增加相关。
Pulm Ther. 2025 Mar;11(1):41-54. doi: 10.1007/s41030-024-00281-z. Epub 2024 Dec 23.
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Investigation of the therapeutic effects and mechanisms of Houpo Mahuang Decoction on a mouse model of chronic obstructive pulmonary disease.厚朴麻黄汤对慢性阻塞性肺疾病小鼠模型的治疗作用及机制研究
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Gut Microbiota-Derived Tryptophan Metabolites Alleviate Allergic Asthma Inflammation in Ovalbumin-Induced Mice.肠道微生物群衍生的色氨酸代谢产物减轻卵清蛋白诱导小鼠的过敏性哮喘炎症
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本文引用的文献

1
High plasma IL-6 levels may enhance the adverse effects of mouse allergen exposure in urban schools on asthma morbidity in children.高血浆白细胞介素 6 水平可能会增强城市学校中老鼠过敏原暴露对儿童哮喘发病率的不良影响。
J Allergy Clin Immunol. 2023 Dec;152(6):1677-1682. doi: 10.1016/j.jaci.2023.06.027. Epub 2023 Aug 3.
2
The evolving landscape of immunotherapy for the treatment of allergic conditions.免疫疗法治疗过敏病症的不断发展。
Clin Transl Sci. 2023 Aug;16(8):1294-1308. doi: 10.1111/cts.13546. Epub 2023 Jun 2.
3
The association of plasma IL-6 with measures of asthma morbidity in a moderate-severe pediatric cohort aged 6-18 years.在一个年龄为6至18岁的中重度儿科队列中，血浆白细胞介素-6与哮喘发病率指标的关联。
J Allergy Clin Immunol Pract. 2021 Jul;9(7):2916-2919.e2. doi: 10.1016/j.jaip.2021.02.047. Epub 2021 Mar 23.
4
Metabolic Dysfunction and Asthma: Current Perspectives.代谢功能障碍与哮喘：当前观点
J Asthma Allergy. 2020 Jul 27;13:237-247. doi: 10.2147/JAA.S208823. eCollection 2020.
5
Effects of interleukin-6 receptor blockade on allergen-induced airway responses in mild asthmatics.白细胞介素-6受体阻断对轻度哮喘患者变应原诱导的气道反应的影响。
Clin Transl Immunology. 2019 Jun 14;8(6):e1044. doi: 10.1002/cti2.1044. eCollection 2019.
6
Treatment of severe persistent asthma with IL-6 receptor blockade.用白细胞介素-6受体阻滞剂治疗重度持续性哮喘。
J Allergy Clin Immunol Pract. 2019 May-Jun;7(5):1639-1642.e4. doi: 10.1016/j.jaip.2019.02.043. Epub 2019 Mar 15.
7
Interleukin-6: Biology, signaling and strategies of blockade.白细胞介素 6：生物学、信号传递及阻断策略。
Cytokine Growth Factor Rev. 2015 Oct;26(5):475-87. doi: 10.1016/j.cytogfr.2015.07.004. Epub 2015 Jul 4.
8
Cluster analysis of obesity and asthma phenotypes.肥胖与哮喘表型的聚类分析。
PLoS One. 2012;7(5):e36631. doi: 10.1371/journal.pone.0036631. Epub 2012 May 11.
9
Sputum IL-6 concentrations in severe asthma and its relationship with FEV1.重度哮喘患者痰液中白细胞介素-6浓度及其与第一秒用力呼气容积的关系。
Thorax. 2011 Jun;66(6):537. doi: 10.1136/thx.2010.136523. Epub 2010 Sep 29.
10
Insulin-sensitive obesity.胰岛素敏感性肥胖。
Am J Physiol Endocrinol Metab. 2010 Sep;299(3):E506-15. doi: 10.1152/ajpendo.00586.2009. Epub 2010 Jun 22.

The chicken or the egg: The role of IL-6 in pediatric obese and allergen-exposed asthma.

作者信息

Kyler Kathryn E, Jones Bridgette L

机构信息

Division of Hospital Medicine, Children's Mercy Kansas City, Kansas City, Mo; School of Medicine, University of Missouri-Kansas City, Kansas City, Mo.

School of Medicine, University of Missouri-Kansas City, Kansas City, Mo; Section of Allergy/Immunology, Children's Mercy Kansas City, Kansas City, Mo; Division of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children's Mercy Kansas City, Kansas City, Mo.

出版信息

J Allergy Clin Immunol. 2023 Dec;152(6):1420-1422. doi: 10.1016/j.jaci.2023.09.037. Epub 2023 Oct 6.

DOI:10.1016/j.jaci.2023.09.037
PMID:37806322
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10952128/
Abstract
摘要