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The association of plasma IL-6 with measures of asthma morbidity in a moderate-severe pediatric cohort aged 6-18 years.在一个年龄为6至18岁的中重度儿科队列中，血浆白细胞介素-6与哮喘发病率指标的关联。
J Allergy Clin Immunol Pract. 2021 Jul;9(7):2916-2919.e2. doi: 10.1016/j.jaip.2021.02.047. Epub 2021 Mar 23.
2
Relationship of adherence to pediatric asthma morbidity among inner-city children.城市内儿童中依从性与小儿哮喘发病率的关系。
Pediatrics. 2002 Jul;110(1 Pt 1):e6. doi: 10.1542/peds.110.1.e6.
3
Associations of IL-4, IL-6, and IL-12 levels in peripheral blood with lung function, cellular immune function, and quality of life in children with moderate-to-severe asthma.中重度哮喘患儿外周血中白细胞介素-4、白细胞介素-6和白细胞介素-12水平与肺功能、细胞免疫功能及生活质量的相关性
Medicine (Baltimore). 2017 Mar;96(12):e6265. doi: 10.1097/MD.0000000000006265.
4
The association between gender and pediatric respiratory morbidity.性别与儿科呼吸疾病的关联。
Pediatr Pulmonol. 2018 Sep;53(9):1225-1230. doi: 10.1002/ppul.24083. Epub 2018 Jun 26.
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Adherence and morbidity following emergency department care among inner-city children with asthma.城市中心哮喘患儿急诊科治疗后的依从性和发病率
J Asthma. 2010 Jun;47(5):545-50. doi: 10.3109/02770901003795323.
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Confirmation of association of IL-15 with pediatric asthma and comparison of different controls.白细胞介素-15与小儿哮喘关联的确认及不同对照的比较
Allergy. 2006 May;61(5):576-80. doi: 10.1111/j.1398-9995.2006.01059.x.
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Cost, morbidity, and control of asthma in Hungary: The Hunair Study.匈牙利哮喘的成本、发病率及控制情况：胡奈尔研究
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Obesity and childhood asthma in male schoolchildren in Saudi Arabia: Is there a role for leptin, interleukin-4, interleukin-5, and interleukin-21?沙特阿拉伯男学生的肥胖与儿童哮喘：瘦素、白细胞介素-4、白细胞介素-5和白细胞介素-21是否起作用？
Ann Saudi Med. 2019 Sep-Oct;39(5):295-301. doi: 10.5144/0256-4947.2019.295. Epub 2019 Oct 3.
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IL-35 and IL-37 are negatively correlated with high IgE production among children with asthma in Saudi Arabia.IL-35 和 IL-37 与沙特阿拉伯哮喘儿童的高 IgE 产生呈负相关。
J Asthma. 2022 Apr;59(4):655-662. doi: 10.1080/02770903.2021.1878533. Epub 2021 Feb 13.
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An exploration of factors underlying asthma care and morbidity: a factor analysis of clinical variables.哮喘护理与发病率潜在因素的探索：临床变量的因子分析
J Allergy Clin Immunol. 2008 Aug;122(2):328-34, 334.e1-5. doi: 10.1016/j.jaci.2008.05.021. Epub 2008 Jun 24.

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Non-T2 asthma.非T2型哮喘
Curr Opin Pulm Med. 2025 May 1;31(3):287-293. doi: 10.1097/MCP.0000000000001154. Epub 2025 Mar 27.
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The Impact of the Indoor Environment on Childhood Asthma.室内环境对儿童哮喘的影响。
Curr Allergy Asthma Rep. 2025 Jan 27;25(1):11. doi: 10.1007/s11882-025-01193-x.
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A clinician's guide to effects of obesity on childhood asthma and into adulthood.临床医生指南：肥胖对儿童哮喘及成年期的影响。
Expert Rev Respir Med. 2024 Oct;18(10):759-775. doi: 10.1080/17476348.2024.2403500. Epub 2024 Sep 16.
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Molecular Pathways and Potential Therapeutic Targets of Refractory Asthma.难治性哮喘的分子途径及潜在治疗靶点
Biology (Basel). 2024 Aug 1;13(8):583. doi: 10.3390/biology13080583.
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Systemic Inflammation in Asthma: What Are the Risks and Impacts Outside the Airway?哮喘中的系统性炎症：气道以外的风险和影响是什么？
J Allergy Clin Immunol Pract. 2024 Apr;12(4):849-862. doi: 10.1016/j.jaip.2024.02.004. Epub 2024 Feb 12.
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Umbilical cord mesenchymal stem cells inhibited inflammation of bronchial epithelial cells by regulating Hedgehog pathway.脐带间充质干细胞通过调节 Hedgehog 通路抑制支气管上皮细胞炎症。
Eur J Histochem. 2023 Dec 12;67(4):3908. doi: 10.4081/ejh.2023.3908.
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The chicken or the egg: The role of IL-6 in pediatric obese and allergen-exposed asthma.先有鸡还是先有蛋：白细胞介素-6在儿童肥胖及暴露于过敏原的哮喘中的作用
J Allergy Clin Immunol. 2023 Dec;152(6):1420-1422. doi: 10.1016/j.jaci.2023.09.037. Epub 2023 Oct 6.
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Effects of Allergen Exposure and Environmental Risk Factors in Schools on Childhood Asthma.过敏原暴露和学校环境风险因素对儿童哮喘的影响。
Curr Allergy Asthma Rep. 2023 Oct;23(10):613-620. doi: 10.1007/s11882-023-01108-8. Epub 2023 Aug 31.
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High plasma IL-6 levels may enhance the adverse effects of mouse allergen exposure in urban schools on asthma morbidity in children.高血浆白细胞介素 6 水平可能会增强城市学校中老鼠过敏原暴露对儿童哮喘发病率的不良影响。
J Allergy Clin Immunol. 2023 Dec;152(6):1677-1682. doi: 10.1016/j.jaci.2023.06.027. Epub 2023 Aug 3.
10
Mechanistic Links Between Obesity and Airway Pathobiology Inform Therapies for Obesity-Related Asthma.肥胖与气道病理生理学之间的机制联系为肥胖相关哮喘的治疗提供了信息。
Paediatr Drugs. 2023 May;25(3):283-299. doi: 10.1007/s40272-022-00554-7. Epub 2023 Jan 19.

本文引用的文献

1
A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma.调节性 T 细胞 Notch4-GDF15 轴在哮喘中的组织炎症中起许可作用。
Nat Immunol. 2020 Nov;21(11):1359-1370. doi: 10.1038/s41590-020-0777-3. Epub 2020 Sep 14.
2
Evidence for Exacerbation-Prone Asthma and Predictive Biomarkers of Exacerbation Frequency.哮喘加重倾向的证据和加重频率的预测生物标志物。
Am J Respir Crit Care Med. 2020 Oct 1;202(7):973-982. doi: 10.1164/rccm.201909-1813OC.
3
Serum IL-6: A biomarker in childhood asthma?血清白细胞介素-6：儿童哮喘的生物标志物？
J Allergy Clin Immunol. 2020 Jun;145(6):1701-1704.e3. doi: 10.1016/j.jaci.2020.01.021. Epub 2020 Jan 28.
4
Treatment of severe persistent asthma with IL-6 receptor blockade.用白细胞介素-6受体阻滞剂治疗重度持续性哮喘。
J Allergy Clin Immunol Pract. 2019 May-Jun;7(5):1639-1642.e4. doi: 10.1016/j.jaip.2019.02.043. Epub 2019 Mar 15.
5
Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation.上皮细胞白细胞介素-6 转导信号定义了一种新的哮喘表型，具有增加的气道炎症。
J Allergy Clin Immunol. 2019 Feb;143(2):577-590. doi: 10.1016/j.jaci.2018.05.026. Epub 2018 Jun 11.
6
An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells.一种与哮喘相关的白细胞介素4受体（IL4R）变体通过促进调节性T细胞向TH17样细胞的转变而加剧气道炎症。
Nat Med. 2016 Sep;22(9):1013-22. doi: 10.1038/nm.4147. Epub 2016 Aug 1.
7
Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts.血浆白细胞介素-6 浓度、代谢功能障碍与哮喘严重程度：两个队列的横断面分析。
Lancet Respir Med. 2016 Jul;4(7):574-584. doi: 10.1016/S2213-2600(16)30048-0. Epub 2016 Jun 6.
8
Role of IL-6 in asthma and other inflammatory pulmonary diseases.IL-6 在哮喘和其他肺部炎症性疾病中的作用。
Int J Biol Sci. 2012;8(9):1281-90. doi: 10.7150/ijbs.4874. Epub 2012 Oct 25.
9
C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus.C反应蛋白、白细胞介素6与2型糖尿病发病风险
JAMA. 2001 Jul 18;286(3):327-34. doi: 10.1001/jama.286.3.327.

The association of plasma IL-6 with measures of asthma morbidity in a moderate-severe pediatric cohort aged 6-18 years.

作者信息

Permaul Perdita, Peters Michael C, Petty Carter R, Cardet Juan Carlos, Ly Ngoc P, Ramratnam Sima K, Ross Kristie, Fitzpatrick Anne, Israel Elliot, Bacharier Leonard B, Phipatanakul Wanda

机构信息

Division of Pulmonology, Allergy and Immunology, NY-Presbyterian Hospital/Weill Cornell Medicine, Weill Cornell Medical College, New York, NY.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, Calif.

出版信息

J Allergy Clin Immunol Pract. 2021 Jul;9(7):2916-2919.e2. doi: 10.1016/j.jaip.2021.02.047. Epub 2021 Mar 23.

DOI:10.1016/j.jaip.2021.02.047
PMID:33771493
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8277679/
Abstract
摘要